|Table of Contents|

Elimination of the Resistance Plasmidin Niconic Acid Hydroxylation Strain Comamonastestosteroni JA1(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2007年02期
Page:
77-80
Research Field:
生命科学
Publishing date:

Info

Title:
Elimination of the Resistance Plasmidin Niconic Acid Hydroxylation Strain Comamonastestosteroni JA1
Author(s):
Yang Yao; Yuan Sheng; Shang Guangdong; Dai Yijun
Jiangsu Key Laboratory of Biodiversity and Biotechnology,Key Lab of Microbial Technology in the School of Life Science,Nanjing Normal University,Nanjing 210097,China
Keywords:
p lasm id elim ina tion;  nico tin ic ac id dehydrogenase;  Com am onastestoste roni JA1;  antib iotic resistance
PACS:
Q78
DOI:
-
Abstract:
Com am onastesto steroni JA1, cata lyzing the hydroxy la tion from n icotin ic ac id to 6- hydroxynico tin icac id, w as found to resist to m any antib io tics. A lkaline lysis ex traction of the JA1 culture reveals a 19 kb p lasm id. 0. 002 5% SDS treatm ent o f the strain e lim inated the ex trachrom osa l plasm id. The m utants lost the kanam ycin res istance ability wh ile keeping the nicotin ic ac id hydroxy lation activ ity.

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Last Update: 2013-05-05