|Table of Contents|

Study on the Molecular Structures and Spectroscopic Properties of Sartan Derivatives(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2008年01期
Page:
71-74
Research Field:
化学
Publishing date:

Info

Title:
Study on the Molecular Structures and Spectroscopic Properties of Sartan Derivatives
Author(s):
Rong Yuzhi1;  Zhao Bo1;  Huang Xiaohua1;  Wu Yun2
1.School of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China
Keywords:
sartan derivatives;  density functiona l theo ry;  e lectron ic spectrum;  fluo rescence spec trum
PACS:
R914
DOI:
-
Abstract:
Irbesartan and va lsartan as sartan der iva tives are synthesized separate ly, and they are fully optim ized at the B3LYP /6- 31G* leve .l The electronic abso rption spectra are calcu lated using tim e dependent density-functiona l theory a t the same leve,l and the fluo rescence spec tra in m ethano l-wa ter so lution arem easured and the ir fluorescence quantum y ields are determ ined. By compar ing the abso rption spectra and fluo rescence em ission spectra o f the tw o compounds, it can be concluded that the p lanarity and conjugation betw een the te trazole ring and benzene ring have an effect on the m ax im um absorption peak; the fluorescence response increases w ith the fo rm ation o f intram o lecular hydrog en bonds, and the fluo rescence em iss ion peaks are g rea tly influenced by the planar ity and con jugation betw een two benzene rings. Irbe sartan and va lsartan have high fluorescence quantum y ie lds and can be used as fluorescence probe to study the interaction m echan ism w ith b io log ica lm acrom o lecules such as DNA, pro te in etc.

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Last Update: 2013-05-05