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Improvement of H2O2 Induced MC3T3-E1 Osteoblast Damage by Aralia echinocauIis Hand. Mazz Flavonoids(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2010年01期
Page:
107-111
Research Field:
生命科学
Publishing date:

Info

Title:
Improvement of H2O2 Induced MC3T3-E1 Osteoblast Damage by Aralia echinocauIis Hand. Mazz Flavonoids
Author(s):
Pei Lingpeng1; Yin Xia2; Cui Jian1; Li Li2; Zhu Jia2
1.Central MINZU University,Institute of Minarity Traditional Medicine Research,Beijing 100081,China  2. China Academy of ChineseMedical Sciences, Wangjing Hosp ital, Institute of Orthopaedics and Traumatology, Beijing 100070, China
Keywords:
MC3T32E1 osteoblast;  free radical;  A ralia echinocauIis Hand. Mazz;  flavonoids
PACS:
R285
DOI:
-
Abstract:
Objective to investigate the effect ofA ralia echinocauIis Hand. Mazz flavonoids on enhances the function of an2 ti2oxidative damage inMC3T32E1 osteoblast. MethodsMC3T32E1 osteoblasts were randomly divided in five group s, in2 cluding control group,model group, A ralia echinocauIis Hand. Mazz flavonoids group [ low dose (1 ×10 - 8 mol/L) 、mid2 dle dose (1 ×10 - 7 mol/L ) 、high dose ( 1 ×10 - 6 mol/L ) ] , whose activity of cells、superoxide dismutase ( SOD) 、the content of reactive oxygen species (ROS) 、lip id oxygen (LPO) and membrane fluidity were tested and compared. Re2 sults compared with model group, the activity of cells、SOD activity and membrane fluidity in A ralia echinocauIis Hand. Mazz flavonoids group swere significantly raised ( P < 0.01). However, the content of ROS and LPO were significantly decreased ( P < 0.01). Conclusion H2O2 can cause oxidative damage ofMC3T32E1 osteoblasts, but A ralia echinocauIis Hand. Mazz flavonoids can p revent and decrease its influence.

References:

[ 1 ] 　邵兴,赵敬华. 浅析自然地理环境与土家族医药学的关系[ J ]. 中国民族民间医药, 2007, 11 (3) : 58-60.
[ 2 ] 　方志先,赵晖,赵敬华. 土家族药物志[M ]. 北京:中国医药科技出版社, 2007: 830-835.
[ 3 ] 　Kim L. Lycopene II2effect on osteoblasts: the carotenoid lycopene stimulates cell p roliferation and alkaline phosphatase activi2 ty of SaOS22 cells[ J ]. J Med Food, 2003, 6 (2) : 79-86.
[ 4 ] 　Jacobson A. Vitamin A differentially regulates RANKL and OPG exp ression in human osteoblasts[ J ]. Biochem Biophys Res Commun, 2004, 322 (1) : 162-167.
[ 5 ] 　Reiter R. Biomarkers of free radical damage: app lications in experimental animals and in human[ J ]. J Pineal Rea, 1995, 18: 1-11.
[ 6 ] 　Chan T Y. Oxidative DNA damage, antioxidants and cancer[ J ]. J Pineal Rea, 1996, 20: 187-191.

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Last Update: 2013-04-08