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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:

2012年02期

Page:

93-96

Research Field:

生命科学

Publishing date:

Info

Title:

Determination of Residual Acetic Acid and N,N-Dimethylformamide in Sulfadoxine by Capillary Gas Chromatography

Author(s):

Jing Yue; Wang Gang; Zhang Ailian; Sheng Xiaoling; Gong Zhunan

School of Life Sciences,Nanjing Normal University,Nanjing 210046,China

Keywords:

sulfadoxine; acetic acid; N; N-Dimethylformamide; capillary gas chromatography; residue

PACS:

R927.11

DOI:

-

Abstract:

Objective: To establish a method for the determination of residual organic solvent，acetic acid and NN-Dimethylformamide( DMF) in sulfadoxine． Method: Capillary gas chromatographic method was introduced for the determination， residual organic solvent was extracted from sulfadoxine with methanol and separated in DB-WAX capillary column with FID detector． Result: the linear relation of acetic acid and NN-Dimethylformamide was Y = 3. 565 7X + 4. 078 4 ( r = 0. 999 3) and Y = 7. 248 9X － 7. 488 9 ( r = 0. 999 6) ，with accuracy RSD ( 1. 8% and 3. 3%) ，recovery rate ( 99. 7% and 100. 1%) ，LOD ( 35. 46 ng /mL and 66. 5 ng /mL) respectively． Conclusion: The method was accurate， reliable and high sensitivity for determination of residual organic solvent in sulfadoxine．

References:

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［2］ Wittmann G，Van Langenhove H，Dewulf J． Determination of acetic acid in aqueous samples，by water-phase derivatisation， solid-phase microextraction and gas chromatography［J］． J Chromatogr A，2000，874( 2) : 225-234．
［3］ 黄京芳，徐沄，彭方，等． 毛细管气相色谱法同时测定盐酸氨溴索中乙醇、醋酸和甲苯残留量［J］． 药物分析杂志， 2005，4 : 466-468．
［4］ 刘红梅，赵阶林． 气相色谱程序升温法测定硝酸异山梨酯有机溶剂的残留量［J］． 首都医药，2005， 12( 14) : 51-52．
［5］ 王存嫦，刘莲英，李添宝． 大口径石英毛细管气相色谱法测定盐酸尼非卡兰中有机残留溶剂［J］． 湘南学院学报: 自然科学版，2004，25( 5) : 58-60．

Memo

Memo:

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Common functions

Last Update: 2013-03-11