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FEN1’s Functional Regulation and Its Link to Cancer(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2014年02期
Page:
7-
Research Field:
Publishing date:

Info

Title:
FEN1’s Functional Regulation and Its Link to Cancer
Author(s):
Zhou Ting; Gao Tingting; Sun Hongfang; Pan Feiyan; He Linfeng; Guo Zhigang
School of Life Sciences,Nanjing Normal University,Jiangsu Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210023,China
Keywords:
FEN1; DNA repair; tumor
PACS:
Q2;Q243
DOI:
-
Abstract:
Flap endonuclease1(FEN1)is a kind of structurespecific multifunctional nuclease which contains 5′->3′ flap endonuclease(FEN)activity,gap endonuclease(GEN)activity and exonuclease(EXO)activity.The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways,including Okazaki fragment maturation,longpatch base excision repair and telomere maintenance.As such,FEN1 must be precisely regulated to execute each of its functions with the right timing and in a specific subcellular location.FEN1 dysfunction will lead to genomic stability and integrity descend,and eventually induce a variety of chromosomal diseases including tumor.This review mainly targets FEN1’s functional regulation and its link to cancer.

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Last Update: 2014-06-30