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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:

2015年02期

Page:

65-

Research Field:

化学

Publishing date:

Info

Title:

Studies on Synthesis of 1-Cyano-indolizine-3-[N-(2-aminoethyl)] Carboxamide and Its Application as Fluorescent Sensors for Cu²⁺

Author(s):

Yang Qian¹; Zang Xinxin¹; Wu Jing²; Wang Bingxiang¹

(1.Jiangsu Key Laboratory of Biofunctional Materials,Jiangsu Research Center of Biomedical Functional Materials Engineering, School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China) (2.School of International Pharmaceutical Business,China Pharmaceutical University,Nanjing 211198,China)

Keywords:

1-cyano-indolizine-3-[N-(2-aminoethyl)]carboxamide; Cu²⁺; fluorescence probes

PACS:

O626

DOI:

-

Abstract:

We report here the synthesis of 1-cyano-indolizine-3-[N-(2-aminoethyl)]carboxamide(No.3 compound)and the study of it as fluorescent probe for Cu²⁺ ions. The structure of the compound 3 was determined by IR,¹H NMR. Its UV and fluorescence spectra were measured. The influences of eight metal ions such as Cu²⁺,Zn²⁺,Ni²⁺,Co²⁺,Mg²⁺,Na⁺,K⁺and Ca²⁺ on its fluorescence property was studied. Spectroscopic study revealed that the compound 3 had rather strong affinity toward Cu²⁺. The specificity of the compound 3 toward Cu²⁺was determined. Nearly no fluorescence intensity changes were observed in emission spectra with Zn²⁺,Ca²⁺,Na⁺,K⁺,Mg²⁺but Ni²⁺ and Co²⁺. However,under identical conditions,the study showed fluorescence quenching from Cu²⁺. So we have developed a new fluorescent sensor. It showed high selectivity toward Cu²⁺ in DMSO.

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Last Update: 2015-06-30