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Effect of Long-Term Exercise on Aminogram in Serum in a Rat Model of Non-Alcoholic Fatty Liver Disease(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2015年02期
Page:
122-
Research Field:
体育学
Publishing date:

Info

Title:
Effect of Long-Term Exercise on Aminogram in Serum in a Rat Model of Non-Alcoholic Fatty Liver Disease
Author(s):
Ye Chun1; He Zhijing2
(1.School of Sport Sciences,Nanjing Normal University,Nanjing 210023,China) (2.Biochemical Department of Nanjing University,Nanjing 210093,China)
Keywords:
non-alcoholic fatty liver disease; exercise; amino-acids
PACS:
G804.5
DOI:
-
Abstract:
The purpose of this paper was to study the changes of aminogram in plasma after long-term exercise in non-alcoholic fatty liver disease(NAFLD)rats. Thirty healthy male SD rats were randomly and equally divided into following 3 groups:normal control group(C,fed with standard diet),high fat diet fed control group(HC)and long-term exercise(HE). The rats in group HC were fed with high-fat diet without exercise for 4 weeks,then with 90 min unloaded swimming 5 times per week. The whole duration of the study were 24 weeks,the serum concentration of free amino-acids and ALT,AST,Glu,Chol,TG,HDL,LDL,CP,the morphological changes of liver was detected. Results:ALT,AST,Glu,Chol,TG,HDL,LDL,CP were increased in HC group,while AST,GLU,LDL decreased,and ALT,CHOL,TG decreased significantly(P<0.05 and P<0.01)respectively in HE group. HDL was increased in HE group comparing with HC group. The steatosis was higher in HC group,but was lower in HE group(P<0.05). The Asp,Cir,Ser,Ala,Tyr,Met,Lys,Arg in the serum of HE group were significantly lower than that in HC group(P<0.01),while Glu,Asn,Thr,Gly,Val,Phe in serum lower than that(P<0.05). The levels of most other amino acids tended to decreased in HE group although there was no significant difference compared with HC group(P>0.05). The content of branched-chain amino acid(BCAA)was little lower(P>0.05)but aromatic amino acid(AAA)was lower in HE group(P<0.05)than that in HC group,Fisher ratio was reduced(P<0.05). Our result indicate that increased fat oxidation during long-term exercise could benenif for liver function. The changed of serum aminogram show long-term can correct the disoder of protein metabolism in some degree.

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Last Update: 2015-06-30