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The Effect of Lycorine on LPS-Induced COX-2 in vivo and vitro(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2016年01期
Page:
86-
Research Field:
生命科学
Publishing date:

Info

Title:
The Effect of Lycorine on LPS-Induced COX-2 in vivo and vitro
Author(s):
Kang Jingjing1; Li Guilan2; Wang Qi2; Yin Zhimin2
（1.Department of Biochemistry，School of Medicine，Huanghe College of Science and Technology，Zhengzhou 450063，China）（2.School of Life Sciences，Nanjing Normal University，Jiangsu Province Key Laboratory for Molecular and Medicine Biotechnology，Nanjing 21002
Keywords:
lycorine; LPS; COX-2; acute lung injury; RAW264.7 cells
PACS:
R392.5
DOI:
-
Abstract:
The object of this study was to explore the effect of lycorine on LPS-induced COX-2 in vivo and vitro. The mice induced by LPS was used as an acute lung injury（ALI）model. The RAW264.7 cells induced by LPS was used as a cell model. The effect of lycorine was evaluated by Western blot for protein expression of COX-2 in lung tissue as well as in RAW264.7 cells. The results showed that lycorine could inhibit the expression of COX-2 protein in vivo and vitro obviously and promote the protein degradation of COX-2 protein in RAW264.7 cells. In conclusion，lycorine could effectively reduce the protein level of COX-2 induced by LPS in vivo and vitro.

References:

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Last Update: 2016-03-30