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Changes and Analysis of Serum Free Aminogram in Non-AlcoholicFatty Liver Disease（NAFLD）Rats(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2016年01期
Page:
90-
Research Field:
生命科学
Publishing date:

Info

Title:
Changes and Analysis of Serum Free Aminogram in Non-AlcoholicFatty Liver Disease（NAFLD）Rats
Author(s):
Ye Chun1; Fang Yu2
（1.Department of Physical Education，Nanjing Normal University，Nanjing 210023，China）（2.Emergency Center of Gulou Hospital Affiliated to Medical College of Nanjing University，Nanjing 210093，China）
Keywords:
non-alcoholic fatty liver disease; serum; amino-acids
PACS:
G804.5
DOI:
-
Abstract:
To elucidate the characteristic changes of serum amino-acid metabolism in NAFLD rats. Twenty SD rats were randomly divided into two groups，standard diet fed group（con）and high fat diet fed group（HF）. The whole duration of the study were 24 weeks，the serum concentration of free amino-acids and ALT，AST，Glu，Chol，TG，HDL，LDL，CP，the morphological changes of liver was detected. The HF rats exhibited severe steatohepatitis；the Asn，Cir，Cit，Tyr，Trp and Phe in the serum of HF group were significantly higher than that in the control group（p<0.001），the levels of most other amino acids tended to increased although there was no significant difference compared with control. Thus the Fischer（BCAA/AAA）ratio was reduced（p<0.05）.The Tau was significantly lower than that in the control（p<0.001）. Our results suggested the increase of HF rats serum free amino acids were related to the insulin resistance and the decreased BACC/AAA was related to the liver cell injury degree. The changed level of serum Cit，Cir and Tau may have more means as potential marker for the early diagnosis of NAFLD and in-depth research.

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Last Update: 2016-03-30