|Table of Contents|

A Comparative Study on Quantification of BinaryPolymorphic Mixtures of Nateglinide by Using PowderX-Ray Diffraction,Differential Scanning Calorimetryand Near Infrared Spectroscopy(PDF)

《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2016年04期
Page:
0-
Research Field:
·生命科学·
Publishing date:

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Title:
A Comparative Study on Quantification of BinaryPolymorphic Mixtures of Nateglinide by Using PowderX-Ray Diffraction,Differential Scanning Calorimetryand Near Infrared Spectroscopy
Author(s):
Qiu JingboXie MengyuShen XiaominZhou DanZhu MurongLi Gang
School of Life Sciences,Testing & Analysis Center,Nanjing Normal University,Nanjing 210023,China
Keywords:
nateglinide polymorphsquantificationpowder X-ray diffractiondifferential scanning calorimetrynear infrared spectroscopy
PACS:
R917
DOI:
10.3969/j.issn.1001-4616.2016.04.013
Abstract:
The aim of this study is to evaluate the ability of powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC)and near infrared(NIR)spectroscopy to quantify two polymorphic forms(B,H)of nateglinide in binary powder mixtures. For this purpose,univariate and multivariate method are developed. The results show that PXRD(with PLS regression)provides a reliable determination of nateglinide samples(predicted accuracy of 89.1%),which is the best choice for quantification of nateglinide polymorphic mixtures in practice,while NIR spectroscopy is the least accurate(predicted accuracy of 79.6%)mainly due to the effect of sample inhomogeneity. Though a good linear relation and a high predicted accuracy(93.4%)for DSC are successfully obtained,it could not be a practical way for low-content quantification in nateglinide polymorphic mixtures.

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Last Update: 2016-12-31