|Table of Contents|

Preparation and Photodynamic Activity of a Water-SolublePhthalocyanine Nanoparticle(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2017年03期
Page:
118-
Research Field:
·化学·
Publishing date:

Info

Title:
Preparation and Photodynamic Activity of a Water-SolublePhthalocyanine Nanoparticle
Author(s):
Zhou Li1; Zhao Guanghui1; Zhou Lin2; Wei Shaohua2
(1.College of Material Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China)(2.School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210046,China)
Keywords:
photodynamic therapy; zinc phthalocyanine; nanocrystalline; photosensitive anticancer activity
PACS:
O644.1
DOI:
10.3969/j.issn.1001-4616.2017.03.017
Abstract:
A novel water soluble nanocrystalline phthalocyanine(NNZnPc-NP)was prepared using reprecipitation method. The surface morphology,stability,singlet oxygen generation ability and photosensitive anticancer activity of it were studied by transmission electron microscopy(TEM),UV-Vis spectrophotometer and inverted fluorescence microscope. The results showed that the particle size of NNZnPc-NP is uniform,the dispersion is good,and it can be stable in aqueous solution. Besides,it also exhibits excellent singlet oxygen generation ability and photostability. The in vitro anticancer experiment results confirm that NNZnPc-NP can efficiently kill HeLa cells under the visible light irradiation. The above results indicate NNZnPc has good potential to be used as clinical photosensitizer for PDT.

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Last Update: 2017-09-30