|Table of Contents|

To Investigate the Value of Anti-Müllerian Hormone in Patientswith Polycystic Ovary Syndrome During in vitro Fertilization(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2018年01期
Page:
88-
Research Field:
·生命科学·
Publishing date:

Info

Title:
To Investigate the Value of Anti-Müllerian Hormone in Patientswith Polycystic Ovary Syndrome During in vitro Fertilization
Author(s):
Li Huimin; Wu Huihua; Meng Qingxia; Zou Qinyan; Li Jianfen; Wang Wei; Li Hong
Center of Reproduction and Genetics,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Suzhou 215002,China
Keywords:
in vitro fertilization-embryo transfer; polycystic ovary syndrome; follicular fluid; anti-Müllerian hormone
PACS:
R711.6
DOI:
10.3969/j.issn.1001-4616.2018.01.016
Abstract:
To compare serum basal and follicular fluid levels of AMH in patients with PCOS and non-PCOS that in the treatment of IVF-ET; analyze the relationship of AMH with clinical characteristics and IVF outcomes of patients with PCOS; further to investigate the value of AMH in patients with PCOS during IVF treatment. A retrospective analysis was performed on patients accepted IVF-ET treatment in our center from August 2010 to June 2012,who were divided into two groups,69 PCOS patients and 95 non-PCOS patients with normal ovulation to analysis the basal serum and follicular fluid AMH levels and IVF outcomes between the two groups. The results showed that,(1)Levels of serum AMH,LH,T,LH/FSH ratio,AFC,BMI and the total number of retrieved oocytes in PCOS group were significantly higher than these of control group(P<0.05).(2)In control group,the serum AMH level has a significantly positive correlation with AFC,the total number of retrieved oocytes and the number of mature eggs(P<0.05),but it has a negative correlation with age(P<0.05); in PCOS group,the serum AMH level has a significantly positive correlation with AFC(P<0.05),but no correlation was found with the total number of retrieved oocytes,the number of mature eggs and age(P>0.05). The serum AMH level has a negative correlation with Gonadotropin dosage in both groups(P<0.05).(3)Levels serum of AMH and follicular fluid have a significantly positive correlation(P<0.05). The AMH level in follicular fluid of normal fertilized oocytes was lower than that of abnormal fertilized oocytes in PCOS group,no difference was found in follicular fluid AMH level between normal and abnormal fertilized oocytes in control group,but follicular fluid AMH level of normal fertilized oocytes in control group was lower than that of PCOS group(P<0.05).(4)No correlation was found between follicular fluid AMH level and corresponding embryo quality in both PCOS and controls(P>0.05). The basal serum AMH level in PCOS patients has a strong correlation with the AFC. A relatively low initial dose of Gonadotropin has an important clinical significance in reducing the incidence of OHSS and obtaining an ideal number of oocytes in PCOS patients with high basal serum AMH and AFC. In addition,the elevated follicular fluid AMH level might affect the potential development of oocyte and its normal fertilization,thus,providing a new marker to predict the oocyte normal fertilization. While the levels of AMH in follicular fluid could not predict the embryo quality and clinical pregnancy outcome.

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Last Update: 2018-03-31