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Long-term Swimming Enhance the Expression of D-bifunctionalProtein and CYP7A1 in Rats Liver of High-fat Diet(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2018年01期
Page:
112-
Research Field:
·生命科学·
Publishing date:

Info

Title:
Long-term Swimming Enhance the Expression of D-bifunctionalProtein and CYP7A1 in Rats Liver of High-fat Diet
Author(s):
Ye Chun
School of Sport Sciences,Nanjing Normal University,Nanjing 210023,China
Keywords:
swimming; high fat diet; CYP7A1; DBP
PACS:
G804.5
DOI:
10.3969/j.issn.1001-4616.2018.01.020
Abstract:
To detect the effect of long term swimming on bile acid classic synthesis pathway in high fat diet rats. Thirty healthy male SD rats were randomly and equally divided into following 3 groups,normal control group(C,fed with standard diet),high fat diet fed control group(HC)and long-term exercise(HE). The rats in group CON were fed in diet control groups and fed with the standard diet. The rats in group HC were continuously fed with high-fat diet without exercise. The rats in group HC were fed with high-fat diet without exercise for 4 weeks,then with 90 min unloaded swimming 5 times per week. The whole duration of the study were 20 weeks,the serum concentration of Glu、Chol、TG、HDL、LDL、CP,and fecal bile acids were assayed. The body and liver weight of rats were recorded. The mRNA levels of hepatic DBP and CYP7A1 were detected by RT-PCR. Serum Glu、TG、chol and LDL were lower in HE group compared HC group(P<0.05). The expression of CYP7A1 and DBP were up-regulation after long-term swimming. The expression of CYP7A1 and DBP could be up-regulated by long-term swimming,thus effectively increasing bile acid excreting and improving the disorders of lipid metabolism.

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Last Update: 2018-03-31