|Table of Contents|

Effects of Acid Polysaccharides from Pleurotus cornucopiaeon the Antioxidation in Mice with Immunosuppression(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2019年04期
Page:
85-90
Research Field:
·生命科学·
Publishing date:

Info

Title:
Effects of Acid Polysaccharides from Pleurotus cornucopiaeon the Antioxidation in Mice with Immunosuppression
Author(s):
Tang Yaqiu; Zhu Yanan; Wang Meiju; Xu Songyang; Li Qiang; Tao Mingxuan
School of Food Science and Pharmaceutical Engineering,Nanjing Normal University,Nanjing 210097,China
Keywords:
APPC; liver; kidney; antioxidant; immune
PACS:
TS201.4
DOI:
10.3969/j.issn.1001-4616.2019.04.012
Abstract:
By using acid polysaccharides from Pleurotus cornucopiae(APPC)as a test material,we established a cyclophosphamide-induced immunosuppressive mouse model and determine the relevant antioxidant index to explore the effect of APPC on the immune activity of liver and kidney in mice. The 72 mice were randomly divided into normal control group,model group,positive control group,as well as high,medium and low APPC dosage group. And by detecting the following antioxidant indexes,including superoxide dismutase(SOD)activity,glutathione(GSH)content,glutathione peroxidase(GSH-Px)activity,catalase(CAT)activity and malondialdehyde(MDA)content,the results could investigate the changes of liver and kidney function characteristics. Compared with the model group,APPC significantly increased SOD activity,GSH-Px activity,CAT activity and GSH content in liver and kidney(P<0.01),and decreased MDA content in liver and kidney(P<0.01). This implies that APPC has a certain improving effect on the immune function of the immune-inhibited mice liver,while betters the immune regulation ability of kidney.

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Last Update: 2019-12-31