|Table of Contents|

Iron-Catalyzed Oxidative Cleavage of Terminal Alkynes toCarboxylic Acids with Hydrogen Peroxide(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2020年02期
Page:
29-33
Research Field:
·化学·
Publishing date:

Info

Title:
Iron-Catalyzed Oxidative Cleavage of Terminal Alkynes toCarboxylic Acids with Hydrogen Peroxide
Author(s):
Yu Xingchen; Xiao Yaping; Han Wei
School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China
Keywords:
alkynes; hydrogen peroxide; iron catalysis; oxidative cleavage; carboxylic acids
PACS:
O62
DOI:
10.3969/j.issn.1001-4616.2020.02.006
Abstract:
An iron-catalyzed oxidative cleavage of alkynes to corresponding carboxylic acids with hydrogen peroxide as oxidant is reported. Using 4-chlorophenylacetylene(1a)as model substrate to optimize reaction conditions shows that optimal result can be obtained with FeCl2 as the catalyst,H2O2 as the oxidant,and acetic acid as the promoter in acetonitrile-water(3:1)at 50 ℃. Under the optimized reaction conditions,a variety of acetylene compounds have been examined. Terminal arylalkynes provide superior yields with broad functional group compatibility. Preliminary Mechanistic studies have also been preformed.

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Last Update: 2020-05-15