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Discussion on the Clinical Value of Serum Test Indicators for the Treatmentand Prognosis of Patients with Chronic Kidney Disease in Different Stages(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2021年01期
Page:
99-103
Research Field:
·生物学·
Publishing date:

Info

Title:
Discussion on the Clinical Value of Serum Test Indicators for the Treatmentand Prognosis of Patients with Chronic Kidney Disease in Different Stages
Author(s):
Yu Qing; Teng Fengmeng
Department of Laboratory Medicine,Jiangsu Province Hospital of TCM,Affilitated Hospital of Nanjing University of TCM,Nanjing 210029,China
Keywords:
HE4; urea; creatinine; chronic kidney disease; complications
PACS:
R446.6
DOI:
10.3969/j.issn.1001-4616.2021.01.014
Abstract:
To explore the application value of serum test indicators in patients with chronic kidney disease(CKD)at different stages in their diagnosis,treatment and prevention of complications. Chemiluminescence and immunoturbidimetric methods were used to detect serum urea,creatinine,uric acid,cystatin C,retinol binding protein and human epididymal protein 4. The relationship between serum indicators of CDK patients of different stages and CDK stages was analyzed,SPSS software analyze the correlation between each index and HE4. There were significant differences in serum urea and creatinine among CKD patients of different stages. Uric acid results showed that CKD 5,CKD 4,and CKD 3 groups were different from CKD 1-2 groups,but there was no difference between CKD 5,CKD 4,and CKD 3 groups. The serum cystatin C and retinol-binding protein of CKD patients of different stages also have significant differences,and the higher the stage,the higher the serum detection indicators. Serum HE4 expression levels of CKD patients of different stages are significantly different,and there is statistical significance between different stages,and with the higher the stage of chronic kidney disease,the higher the serum HE4 level of patients. Different analysis of the correlation between serum HE4 and urea,creatinine,uric acid,cystatin C,retinol-binding protein and PTH in CKD patients found that serum HE4 is related to UREA,CREA,CysC,RBP and PTH. The correlation coefficient and 95% CI were 0.741 4(0.66-0.80),0.826 7(0.77-0.87),0.849 0(0.80-0.89),0.643 7(0.54-0.73)and 0.436 0(0.28-0.57),respectively. However,the correlation between serum HE4 and UA is poor,and its correlation coefficient and 95% CI are 0.204 3(0.04-0.35). HE4 and CREA have the same effect on chronic kidney disease staging. The ROC curve area of urea analysis of chronic kidney disease is 0.971 2,and the ROC curve area of cystatin C analysis of chronic kidney disease is 0.903 7. HE4 can be used as one of the auxiliary diagnostic indicators of CKD staging. GFR combined with HE4 can better know the staging of CKD. Serum PTH can be used as a monitoring indicator for the complications of kidney disease-mineral-bone metabolism in CKD patients. Serological indicators of CDK patients in different stages are of great value for the diagnosis,treatment and prevention of complications.

References:

[1] DELANAYE P. Detection of decreased glomerular filtration rate in intensive care units:serum cystatin C versus serum creatinine[J]. BMC nephrology,2014,15(1):9.
[2]TREIBER M,BALON B P,GORENJAK M. A new serum cystatin C formula for estimating glomerular filtration rate in newborns[J]. Pediatric nephrology,2015,30(8):1297-1305.
[3]史武奇,张芝亚,李冰,等. 血肌酐与胱抑素C在慢性肾脏病诊断及评估肾功能损伤程度中的应用[J]. 解放军医药杂志,2017,29(5):89-92.
[4]程悠悠,黄庆,叶宏伟. NGAL和Cys C对脓毒症相关急性肾损伤的早期诊断学意义[J]. 华南国防医学杂志,2016(8):496-499.
[5]ANA C L M,MARIA I D R,LIDIA R M,et al. Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis:a systematic review and meta-analysis[J]. International journal of gynecological cancer:official journal of the International Gynecological Cancer Society,2014,24(7):1222-1231.
[6]CHEN Y,CHEN Q,LIU Q,et al. Human epididymis protein 4 expression positively correlated with miR-21 and served as a prognostic indicator in ovarian cancer[J]. Tumor biology,2016,37(6):8359-8365.
[7]李丽,刘芳. HE4与肾纤维化[J]. 中国中西医结合肾病杂志,2014(7):656-658.
[8]NAGY B,KRASZNAI Z T,BALLA H,et al. Elevated human epididymis protein 4 concentrations in chronic kidney disease.[J]. Annals of clinical biochemistry,2012,49(4):377-380.
[9]YUAN T F,LI Y. Human epididymis protein 4 as a potential biomarker of chronic kidney disease in female patients with normal ovarian function[J]. Laboratory medicine,2017,48(3):238-243.

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Last Update: 2021-03-15