|Table of Contents|

Identification and Bioinformatics Analysis of AXIN1 Gene inHomo sapiens and Loxodonta africana(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2021年02期
Page:
69-79
Research Field:
·生物学·
Publishing date:

Info

Title:
Identification and Bioinformatics Analysis of AXIN1 Gene inHomo sapiens and Loxodonta africana
Author(s):
Yu Fangfang; Chai Simin; Gu Long; Zheng Yu; Zhou Xu; Xu Shixia; Ren Wenhua
School of Life Sciences,Nanjing Normal University,Nanjing 210023,China
Keywords:
Cryptorchidism; AXIN1; gene identification; bioinformatics analysis
PACS:
Q594
DOI:
10.3969/j.issn.1001-4616.2021.02.011
Abstract:
Cryptorchidism is one of the most common congenital abnormalities of the male genitalia. Under normal conditions,a man’s testis have dropped to the scrotum at birth,while the testes of the Loxodonta africana are always in the abdominal cavity and they can reproduce normally. In this paper,we have identified the differences of cryptorchidism-related gene AXIN1 between Homo sapiens and Loxodonta africana through cloning and sequencing,and conducted bioinformatics analysis on its structure and physical and chemical properties. The results show that,compared with Homo sapiens,the AXIN1 gene lacks the 9th exon(108 bp)in Loxodonta africana; the physical and chemical properties,signal peptide,transmembrane region,phosphorylation site,sub-localization and structural domain information of the AXIN1 gene in the two species are not significant difference; but there are differences in core promoter,protein interaction,secondary structure and three-dimensional structure. This study preliminarily proves that the deletion of the 9th exon of the AXIN1 gene of Loxodonta africana has caused some important changes in protein properties,which lays the foundation for future exploration of whether these changes are related to the location of the testis.

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Last Update: 2021-06-30