|Table of Contents|

Research Progress of Gonadotropin-releasing Hormone Analogs in Assisted Reproductive Technology(PDF)

《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2023年04期
Page:
68-73
Research Field:
生物学
Publishing date:

Info

Title:
Research Progress of Gonadotropin-releasing Hormone Analogs in Assisted Reproductive Technology
Author(s):
Zhou YutianMeng YanDiao FeiyangLiu Jinyong
(Reproductive Medicine Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036,China)
Keywords:
gonadotropin-releasing hormone analogs assisted reproductive technology controlled ovarian stimulation trigger luteal phase support
PACS:
R711.6
DOI:
10.3969/j.issn.1001-4616.2023.04.010
Abstract:
Gonadotropin-releasing hormone analogs,consisting of gonadotropin-releasing hormone agonist and gonadotropin-releasing hormone antagonist,are involved in multiple links of the process of in vitro fertilization. Continuous exploration of different ovulation promotional protocols has led to the increased pregnancy rate. Recently,the role of GnRH-a in achieving final follicular maturation was intensively investigated. Luteal phase support with GnRH-a improves pregnancy outcomes,while more researches are needed to explore applicable population and the most effective protocol. This paper reviews specific applications of GnRH analogs in assisted reproductive technology to provide reference for clinical treatment.

References:

[1]PORTER R N,SMITH W,CRAFT I L,et al. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins[J]. Lancet,1984,2(8414):1284-1285.
[2]FRYDMAN R,CORNEL C,DE ZIEGLER D,et al. Prevention of premature luteinizing hormone and progesterone rise with a gonadotropin-releasing hormone antagonist,Nal-Glu,in controlled ovarian hyperstimulation[J]. Fertility and sterility,1991,56(5):923-927.
[3]SCHALLY A V,ARIMURA A,BABA Y,et al. Isolation and properties of the FSH and LH-releasing hormone[J]. Biochemical and biophysical research communications,1971,43(2):393-399.
[4]CHEN A,YAHALOM D,BEN-AROYA N,et al. A second isoform of gonadotropin-releasing hormone is present in the brain of human and rodents[J]. FEBS letter,1998,435(2-3):199-203.
[5]HISLOP J N,MADZIVA M T,EVEREST H M,et al. Desensitization and internalization of human and xenopus gonadotropin-releasing hormone receptors expressed in alphaT4 pituitary cells using recombinant adenovirus[J]. Endocrinology,2000,141(12):4564-4575.
[6]MAGGI R,CARIBONI A M,MARELLI M M,et al. GnRH and GnRH receptors in the pathophysiology of the human female reproductive system[J]. Human reproduction update,2016,22(3):358-381.
[7]TARLATZIS B C,BILI H N. Gonadotropin-releasing hormone antagonists:impact of IVF practice and potential non-assisted reproductive technology applications[J]. Current opinion in obstetrics & gynecology,2003,15(3):259-264.
[8]NIEDERBERGER C,PELLICER A,COHEN J,et al. Forty years of IVF[J]. Fertility and sterility,2018,110(2):185-324.
[9]MACKLON N S,STOUFFER R L,GIUDICE L C,et al. The science behind 25 years of ovarian stimulation for in vitro fertilization[J]. Endocrine reviews,2006,27(2):170-207.
[10]BROKEMANS F J,BEMARDUS R E,BERKHOUT G. Pituitary and ovarian suppression after early follicular and mid-luteal administration of a LHRH agonist in a depot formulation:Decapeptyl CR[J]. Gynecol endom'nol,1992,6(3):153-161.
[11]MELDRUM D R,WISOT A,HAMILTON F,et al. Timing of initiation and dose schedule of leuprolide influence the time course of ovarian suppression[J]. Fertility and sterility,1988,50(3):400-402.
[12]RON-EL R,HERMAN A,GOLAN A,et al. The comparison of early follicular and midluteal administration of long-acting gonadotropin-releasing hormone agonist[J]. Fertility and sterility,1990,54(2):233-237.
[13]URBANCSEK J,WITTHAUS E. Midluteal buserelin is superior to early follicular phase buserelin in combined gonadotropin-releasing hormone analog and gonadotropin stimulation in in vitro fertilization[J]. Fertility and sterility,1996,65(5):966-971.
[14]EDWARDS R G,MORCOS S,MACNAMEE M,et al. High fecundity of amenorrhoeic women in embryo-transfer programmes[J]. Lancet,1991,338(8762):292-294.
[15]REN J,SHA A,HAN D,et al. Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?[J]. Fertility and sterility,2014,102(1):75-81.
[16]ZHANG Y,ZHAO W,HAN Y,et al. The follicular-phase depot GnRH agonist protocol results in a higher live birth rate without discernible differences in luteal function and child health versus the daily mid-luteal GnRH agonist protocol:a single-centre,retrospective,propensity score matched cohort study[J]. Reproductive biology and endocrinology,2022,20(1):140.
[17]XU B,GEERTS D,HU S,et al. The depot GnRH agonist protocol improves the live birth rate per fresh embryo transfer cycle,but not the cumulative live birth rate in normal responders:a randomized controlled trial and molecular mechanism study[J]. Human reproduction,2020,35(6):1306-1318.
[18]AL-INANY H G,YOUSSEF M A,AYELEKE R O,et al. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology[J]. Cochrane database of systematic reviews,2016,4(4):CD001750.
[19]YANG J,ZHANG X,DING X,et al. Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred:real-word data of 18,853 women from China[J]. Reproductive biology and endocrinology,2021,19(1):124.
[20]HUANG Y,SHUAI M,YUE L,et al. Application of antagonist regimen in patients with failed pregnancy assisted by previous long-term regimen during early follicular phase[J]. American journal of translational research,2021,15; 13(7):8365-8371.
[21]KHALAF M,MITTRE H,LEVALLET J,et al. GnRH agonist and GnRH antagonist protocols in ovarian stimulation:differential regulation pathway of aromatase expression in human granulosa cells[J]. Reproductive biomedicine online,2010,21(1):56-65.
[22]WINKLER N,BUKULMEZ O,HARDY D B,et al. Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells[J]. Fertility and sterility,2010,94(5):1832-1839.
[23]XU D F,LIU P P,FAN L,et al. GnRH antagonist weakens endometrial stromal cells growth ability by decreasing c-kit receptor expression[J]. Reproductive biology and endocrinology,2022,20(1):29.
[24]ZHANG D,HAN M,ZHOU M,et al. Down-regulation of S100P induces apoptosis in endometrial epithelial cell during GnRH antagonist protocol[J]. Reproductive biology and endocrinology,2021,19(1):99.
[25]CARDOZO E R,THOMSON A P,KARMON A E,et al. Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls:a 17-year experience[J]. Journal of assisted reproduction and genetics,2015,32(4):587-596.
[26]NAJDECKI R,MICHOS G,PEITSIDIS N,et al. Agonist triggering in oocyte donation programs-Mini review[J]. Front endocrinol,2022,13:838236.
[27]CIMADOMO D,VAIARELLI A,PETRIGLIA C,et al. Oocyte competence is independent of the ovulation trigger adopted:a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer[J]. Journal of assisted reproduction and genetics,2021,38(6):1419-1427.
[28]王雪金,张宏展,胡晓东 等. 促性腺激素释放激素激动剂单扳机后不同反应对IVF-ET胚胎结局的影响[J]. 生殖医学杂志,2022,31(11):1506-1512.
[29]THORNE J,LOZA A,KAYE L,et al. Euploidy rates between cycles triggered with gonadotropin-releasing hormone agonist and human chorionic gonadotropin[J]. Fertility and sterility,2019,112(2):258-265.
[30]MIZRACHI Y,HOROWITZ E,FARHI J,et al. Ovarian stimulation for freeze-all IVF cycles:a systematic review[J]. Human reproduction update,2020,26(1):118-135.
[31]SHAPIRO B S,DANESHMAND S T,GARNER F C,et al. Gonadotropin-releasing hormone agonist combined with a reduced dose of human chorionic gonadotropin for final oocyte maturation in fresh autologous cycles of in vitro fertilization[J]. Fertility and sterility,2008,90(1):231-233.
[32]HU K L,WANG S,YE X,et al. GnRH agonist and hCG(dual trigger)versus hCG trigger for follicular maturation:a systematic review and meta-analysis of randomized trials[J]. Reproductive biology and endocrinology,2021,19(1):78.
[33]YAN M H,CAO J X,HOU J W,et al. GnRH agonist and hCG(Dual Trigger)versus hCG trigger for final oocyte maturation in expected normal responders with a high immature oocyte rate:study protocol for a randomized,superiority,parallel group,controlled trial[J]. Front endocrinol,2022,13:831859.
[34]HAAS J,BASSIL R,SAMARA N,et al. GnRH agonist and hCG(dual trigger)versus hCG trigger for final follicular maturation:a double-blinded,randomized controlled study[J]. Human reproduction,2020,35(7):1648-1654.
[35]ZHOU C,YANG X,WANG Y,et al. Ovulation triggering with hCG alone,GnRH agonist alone or in combination?A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles[J]. Human reproduction,2022,37(8):1795-1805.
[36]SONG M,LIU C,HU R,et al. Administration effects of single-dose GnRH agonist for luteal support in females undertaking IVF/ICSI cycles:a meta-analysis of randomized controlled trials[J]. Experimental and therapeutic medicine,2020,19(1):786-796.
[37]TESARIK J,HAZOUT A,MENDOZA C. Enhancement of embryo developmental potential by a single administration of GnRH agonist at the time of implantation[J]. Human reproduction,2004,19(5):1176-1180.
[38]FUSI F M,BRIGANTE C M,ZANGA L,et al. GnRH agonists to sustain the luteal phase in antagonist IVF cycles:a randomized prospective trial[J]. Reproductive biology and endocrinology,2019,17(1):103.
[39]KUNG H F,CHEN M J,GUUA H F,et al. Luteal phase support with decapeptyl improves pregnancy outcomes in intracytoplasmic sperm injection with higher basal follicle-stimulating hormone or lower mature oocytes[J]. Journal of the Chinese medical association:JCMA,2014,77(10):524-530.
[40]SALANG L,TEIXEIRA D M,SOLA I,et al. Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse[J]. Cochrane database of systematic reviews,2022,(8):112.

Memo

Memo:
-
Last Update: 2023-12-15