|Table of Contents|

Interaction Between Indolizine-Naphthoquinones and CT-DNA by Cyclic Voltammetry(PDF)

《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2007年01期
Page:
64-67
Research Field:
化学
Publishing date:

Info

Title:
Interaction Between Indolizine-Naphthoquinones and CT-DNA by Cyclic Voltammetry
Author(s):
Li JingDu JiangyanWang BingxiangGong MeijuanLuo Peng
School of Chemistry and Environmental Science,Nanjing Normal University,Nanjing 210097,China
Keywords:
indo lizine-naphthoqu inones CT-DNA interaction e lec trochem ica l action
PACS:
R91
DOI:
-
Abstract:
The inte raction o f four indo lizine-naphthoquinones and CT-DNA was stud ied by cy clic vo ltamm etry at g lass carbon e lectrode. The results ind ica ted that there we re tw o couples o f redox peaks and the redox reaction was contro lled m a inly by diffusion from the curve o f Ip vs scan rate. The currents and peaks o f indo lizine-naphthoqu inones decreased and shifted to the positive d irection by adding CT-DNA in pH = 7.2 PBS so lu tion. It can be suggested tha t the inte raction be tw een indo lizine- naph thoquinones and DNA m ay be in the interca la tive mode in the pH = 7. 2 phospha te buffe r solution.

References:

[ 1] 管鹏健, 徐德锋, 李绍顺. 萘醌类化合物抗肿瘤活性进展[ J] . 中国药物化学杂志, 2004, 14( 4): 249-256.
[ 2] Ra jeshw ar P V, Cprw in H. E lucida tion of structure-activ ity re la tionsh ips for 2-or 6- substituted-5, 8-dim ethoxy-1, 4-naphthoqu inones[ J]. B ioorg& M ed Chem, 2004, 12( 22): 5 997-6 009.
[ 3] Park H J, LeeH J, Lee E J, et a.l Cy to tox ic ity and DNA topo isome rase inhibitory activ ity of benz[ f] indo le-4, 9-d ione analogs[J]. B iosc i B io techno l B iochem, 2003, 67( 9): 1 944-1 949.
[ 4] T ing C Y, H su C T, H su H T, et a.l Isod iospyrin as a nove l hum an DNA topo isom erase I inh ib itor[ J] . B iochem Pha rm,2003, 66( 10): 1 981-1 991.
[ 5] S ilvaM N, Ferre iraV F, SouzaM C B V. An overv iew o f the chem istry and pharmaco logy of naphthoquinones w ith em phasis on be ta- lapachone and der ivatives[ J]. Qu im ica Nova, 2003, 26( 3): 407-416.
[ 6] 王炳祥, 何婷, 胡宏纹. 二铬酸氢吡啶合钴(Ⅱ )存在下吡啶叶立德与1, 4-萘醌的反应[ J]. 化学学报, 2003, 61( 6):889-892.
[ 7] M ichae lT C, M a riso lR, A llen J B. Vo ltamm etr ic stud ies o f the interaction o fm eta l che la tes w ith DNA 2 tris- chelated comp
lexes o f coba lt(Ⅲ ) and iron(Ⅱ ) w ith 1, 10-phenanthro line and 2, 2’ -bipy rid ine[ J] . J Am Chem Soc, 1989, 111( 24):8 901-8 911.
[ 8] M ichae lT C, A llen J B ard. Vo ltamm etric stud ies of the interac tion o f tr is( 1, 10-phenanthroline) coba lt(Ⅱ ) w ith DNA[ J]. J Am Chem Soc, 1987, 109( 24): 7 528-7 530.
[ 9] Xu X H, A llen J B. Imm obilization and hybridization of DNA on an a lum inum (Ⅲ ) a lkaneb ispho sphonate thin film w ith electrog enerated chem ilum inescent detection[ J]. J Am Chem Soc, 1995, 117( 9): 2 627-2 631.
[ 10] M ar iso l R, A llen J B. E lectrochem ical stud ies o f the interaction o fm eta l che la tesw ith DNA 4 vo ltamm etric and e lectrogenerated chem ilum inescent stud ies o f the interac tion o f tr is( 2, 2’-b ipyr idine) o sm ium ( Ⅱ ) w ith DNA[ J]. Anal Chem, 1990,62( 24): 2 658-2 662.

Memo

Memo:
-
Last Update: 2013-05-05