|Table of Contents|

Study of the Thermal Stability of Milrinone(PDF)

《南京师范大学学报》(自然科学版)[ISSN:1001-4616/CN:32-1239/N]

Issue:
2013年03期
Page:
53-56
Research Field:
化学
Publishing date:

Info

Title:
Study of the Thermal Stability of Milrinone
Author(s):
Wang Fang1Sheng Shenjun12Zhao Dingyong2Wang Xiaoshu3Chen Huaming4
(1.Analysis and Testing Center,Nanjing Normal University,Nanjing 210023,China) (2.School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China) (3.Institute of Forensic Sciences,Soochow University,Suzhou 215000,China) (4.Chemzam Phamtech Co.Ltd,Nanjing 210028,China)
Keywords:
MilrinoneTGAstabilitykinetics
PACS:
O642.3
DOI:
-
Abstract:
Thermogravimetric analysis(TGA)was used to study the thermal decomposition kinetics of Milrinone in the nitrogen atmosphere.The thermal decomposition kinetic parameters of activation energies(E)and pre-exponential factors(lnA)of Milrinone were calculated by the Flynn-Wall-Ozawa method and Kissinger method.The results showed that the activation energy Ea of the drug that calculated by the two methods were similar.The average activation energy Ea was 165.69 kJ/mol,pre-exponential factors lnA was 32.44 s-1,the reaction order of the thermal decomposition of Milrinone was 1.00.The store period of this drug was four years under 298.15 K.The thermalgravimetric analysis is a rapid,convenient and feasible method for discussing the stability and the store period of the drug,and the results of this experiment provide a reference for production and appraisal of Milrinone drug.

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Last Update: 2013-09-30