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Inhibition Effects of the Proliferation and Induction of the Apoptosis Of Celastrol In C2C12 Cells(PDF)


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Inhibition Effects of the Proliferation and Induction of the Apoptosis Of Celastrol In C2C12 Cells
Xu YanhuaLiu JinChen Huaqun
Jiangsu Key Laboratory for Molecular and Medical Biotechnology,School of Life Sciences, Nanjing Normal University,Nanjing 210023,China
CelastrolC2C12 myoblastcell proliferationcell apoptosis
Celastrol is an effective content extracted from god vine,a traditional herb.It has been widely used in the treatment of arthritics and nephritis.Recently,it has further been found to suppress the proliferation of tumor cells,and as a potential candidate to treat tumor.We report in this study that in vitro,Celastrol inhibits the proliferation of mouse myoblast,C2C12 cells,as well as induces apoptosis through activation of Caspase-3.Our datas suggest that the safety of Celastrol is needed to be further investigated.


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Last Update: 2013-09-30