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Nutrient Sensing and the Circadian Clock(PDF)


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Nutrient Sensing and the Circadian Clock
Liu Chang
School of Life Sciences,Nanjing Normal University,Nanjing 210023,China
circadian clockenergy metabolismnutrient signalsintegration
The circadian system synchronizes behavioral and physiological processes with daily changes in the external light-dark cycle,optimizing energetic cycles with the rising and setting of the sun.Molecular clocks are organized hierarchically,with neural clocks orchestrating the daily switch between periods of feeding and fasting,and peripheral clocks generating 24 h oscillations of energy storage and utilizations.Recent studies indicate that clocks respond to nutrient signals,and that high-fat diet influences the period of locomotor activity under free-running conditions,a core property of the clock.A major goal is to identify the molecular basis for the reciprocal relationship between metabolic and circadian pathways.In this review,we will discuss the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems.


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Last Update: 2014-09-30