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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:

2015年03期

Page:

76-

Research Field:

生命科学

Publishing date:

Info

Title:

ThermostabilityandCrystalStructureofMiriplatin，aNovelPlatinum-BasedAntitumorDrug

Author(s):

ShengYue; QiuJingbo; LiGang; ZhouDan; ZhuMurong

Test&AnalysisCenter，NanjingNormalUniversity，Nanjing210023，China

Keywords:

miriplatin; thermalanalysis; X-raypowderdiffraction; polymorph

PACS:

R917

DOI:

-

Abstract:

Thepurposeofthisstudyistoinvestigatethethermostabilityandthecrystalstructureofanovelantitumordrugmiriplatin.Thethermostabilityofmiriplatinwasanalyzedusingthermalanalysis（DSC-TG），andcrystalstructurewasdeterminedusingtheX-raypowderdiffraction（XPRD）within-situhightemperatureaccessories.Theresultsshowedthatmiriplatincontainsonemolewaterofcrystallization.Whenheatedto51.64℃，miriplatinwouldlosethewaterofcrystallization.Andaslightpolymorphicphasetransitionhappenedat74.18℃，frommetastablestatetostablestate.Miriplatinwouldtransformintoamorphousphaseat210℃，andfuseat221.81℃.Thisstudyprovidesacomprehensivereferenceforthequalityevaluationofmiriplatin.

References:

［1］TomozawaY，NittaN，OhtaS，etal.Antitumoreffectofmiriplatin-lipiodolsuspension/emulsionusingaVX2livertumormodel［J］.JpnJRadiol，2013，31：662-667.
［2］OguroS，HashimotoS，TanakaT，etal.Short-termtherapeuticeffectsoftranscatheterarterialchemoembolizationusingmiriplatin-lipiodolsuspensionforhepatocellularcarcinoma［J］.JpnJRadiol，2012，30：735-742.
［3］ZhaoJ，MaJJ.Progressinpharmacologicalandclinicalstudiesofmiriplatinoninterventionaltherapyofhepatocellularcarcinoma［J］.ChinJofNewDrugs，2012，21：2097-2099.
［4］ZhaoYN，ChenXQ，ZhuK，etal.Thermostabilityandcrystalstructureofanticancerdrugdasatinib［J］.ActaPharmSin，2011，46：1104-1107.
［5］ZhangH，ZhaoYN，LiG.Studyonpolymorphismandthermostabilityofminodronicacid［J］.ChinJPharmAnal，2012，32：1771-1773.
［6］Petru?evskiG，[Zbacnik]M，Kajd?anoskaM，etal.Pholcodinemonohydrate：crystalstructureandpolymorphism［J］.JCrystGrowth，2013，375：119-124.
［7］LiG，QinT，HuangCG，etal.CompositionandthermalstabilityofthemineraltraditionalChinesemedicinepyrite（Zirantong）［J］.ActaChimSin，2009，27：466-470.
［8］WangQK，ZhouLM，PuSP，etal.Synthesisofmiriplatin，anovelplatinum-basedantitumor-drug［J］.ChinPharmJ，2013，48：1594-1595.
［9］WangQK，PuSP，ZhuZB，etal.Improvedsynthesisofmiriplatin，anantitumordrug［J］.ChinJofMedChem，2012，22：36-37.
［10］WangQK，PuSP，ZhuZB，etal.Anewsyntheticmethodandcharacterizationofmiriplatin，anantitumordrug［J］.ChinJofMedChem，2011，21：213-215.

Memo

Memo:

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Common functions

Last Update: 2015-09-30