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The Functions of Health Care and Application ofStevia rebaudiana and Stevioside(PDF)


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The Functions of Health Care and Application ofStevia rebaudiana and Stevioside
Chen Yuru1Yang Fengping1Yang Fan2Song Tingting1Su Chenjie1Yin Huihui1
(1.School of Life Sciences,Nanjing Normal University,Jiangsu Engineering and Technology Research Center forMicrobiology Resource,Jiangsu Key Laboratory for Biodiversity and Biotechnology,Jiangsu KeyLaboratory for Microbes and Functional Genomic,Nanjing
Stevia rebaudianasteviosidemedicinal functionchlorogenic aciddicaffeoylquinic acid
Stevia rebaudiana,a well-performed economic crop,is known as the world’s third largest source of sweeteners and raw material for healthy products. As the population with obesity,diabetes and other metabolic disorders or diseases increases in modern society,people draw more attentions to new plant-based natural products with health benefits. Stevioside,extracted from the plant species,is a safe and green sweetener with high sweetness and low calorific value. It is suitable for all kinds of people,especially patients with obesity,diabetes,hypertension,hyperlipidemia and other diseases as a sugar substitute. Stevia rebaudiana also contains chlorogenic acid,dicaffeoylquinic acid,flavonoids and other bioactive constituents,which have medicinal functions and health benefits. Therefore,the development of new healthy products containing stevioside and the application of stevia tea and stevia wine has excellent promising prospects in the future.


[1] 舒世珍. 甜菊引种三十年[J]. 中国种业,2010(6):21-22.
[2] ROBERTO L M,ANTONIO V G,LILIANA Z B,et al. Stevia rebaudiana Bertoni,source of a high-potency natural sweetener:a comprehensive review on the biochemical,nutritional and functional aspects[J]. Food chemistry,2012,132:1 121-1 132.
[3] THIYAGARAJAN M,VENKATACHALAM P. Large scale in vitro propagation of Stevia rebaudiana(bert)for commercial application:pharmaceutically important and antidiabetic medicinal herb[J]. Industrial crops and products,2012,37:111-117.
[4] SIDD P,GEORGE P J R,BARRY L,et al. In vitro metabolism of rebaudioside B,D,and M under anaerobic conditions:comparison with rebaudioside A[J]. Regulatory toxicology and pharmacology,2014(68):259-268.
[5] 胡献丽,董文宾. 甜菊及甜菊糖研究进展[J]. 食品研究与开发,2005,26(1):36-38.
[6] 胡静,陈育如. 大孔树脂D107和D108对甜菊糖中SS和RA的分离研究[J]. 食品研究与开发,2008,29(6):1-4.
[7] 陈育如,刘虎,姜中玉. 一种生物转化甜菊糖中甜菊苷为甜菊双糖苷的方法:201010170786.3[P]. 2010-10-17.
[8] 姜中玉,陈育如,刘虎. 一株将甜菊苷转化为甜茶苷的细菌鉴定及转化特性研究[J]. 微生物学报,2011,51(1):43-48.
[9] TIRAPELLI C R,AMBROSIO S R,DE OLIVEIRA A M,et al. Hypotensive action of naturally occurring diterpenes:a therapeutic promise for the treatment of hypertension[J]. Fitoterapia,2010,81(7):690-702.
[10] YANG P S,LEE J J,TSAO C W,et al. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals[J]. Neuroscience letters,2009,454(1):72-75.
[11] LAILERD N,SAENGSIRISUWAN V,SLONIGER J A,et al. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle[J]. Metabolism-clinical and experimental,2004,53(1):101-107.
[12] BARRIOCANAL L A,PALACIOS M,BENITEZ G,et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in type 1 and type 2 diabetics[J]. Regulatory toxicology and pharmacology,2008,51(1):37-41.
[13] KATAEV V,STROBYKIN I Y,ANDREEVA O V,et al. Synthesis and antituberculosis activity of derivatives of stevia rebaudiana glycoside steviolbioside and diterpenoid isosteviol containing hydrazone hydrazide,and pyridinoyl moieties[J]. Russian journal of bioorganic chemistry,2011,37(4):483-491.
[14] KOROCHKINA M G,SHARIPOVA R R,STROBYKINA I Y,et al. Synthesis and antimicrobial and antifungal activity of derivatives of the diterpenoid isosteviol and the glycoside steviolbioside containing onium nitrogen atoms[J]. Pharmaceutical chemistry journal,2011,44(11):597 -600.
[15] LIN L H,LEE L W,SHEU S Y,et al. Study on the stevioside analogues of steviolbioside,steviol,and isosteviol 19-alkylamide dimers:synthesis and cytotoxic and antibacterial activity[J]. Chemical & pharmaceutical bulletin,2004,52(9):1 117-1?122.
[16] 钟映富,胡翔,周正科,等. 甜茶及其开发利用[J]. 西南园艺,2001,29(4):56-57.
[17] 谢莹,陈全斌,罗达伟,等. 高纯度甜茶苷抗疲劳及免疫调节功能研究[J]. 时珍国医国药,2010,21(6):1 421-1 422.
[18] KOH G Y,MCCUTCHEON K,ZHANG F,et al. Improvement of obesity phenotype by chinese sweet leaf tea(rubus suavissimus)components in high-fat diet-induced obese rats[J]. Journal of agricultural and food chemistry,2011,59(1):98-104.
[19] LI J,ZHANG D Y,WU X M. Synthesis and biological evaluation of novel exomethylene cyclopentanone tetracyclic diterpenoids as antitumor agents[J]. Bioorganic & medicinal chemistry letters,2011,219(1):130-132.
[20] FRAN?OIS N M A,RACHID S,BABAKAR D. Study on chemical composition and biological activities of essential oil and extracts from Stevia rebaudiana Bertoni leaves[J]. LWT-food science and technology,2011,1(8):2-8.
[21] 陈育如,唐刚,刘虎,等. 烟草废料中咖啡酰奎尼酸的提取工艺研究[J]. 生物加工过程,2009,7(6):55-58.
[22] 张海娟,刘玲,郑晓涛,等. 菊芋叶片中绿原酸的提取工艺条件优化研究[J]. 食品工业科技,2011,32(5):261-262,265.
[23] 周志娥,罗秋水,熊建华,等. 绿原酸、异绿原酸A对大肠杆菌的抑菌机制[J]. 食品科技,2014,39(3):228-232.
[24] MAI T T N,SURESH A,YASUHIRO T,et al. Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense[J]. Journal of thieme,2006,72(1):46-51.
[25] BRUNA K B,PRISCILA C,GLAUCIA R B M,et al. Chlorogenic acids reduces the glucose peak in the oral glucose tolerance test:effects on hepatic glucose release and glycaemia[J]. Cell biochemistry and function,2008,26(3):320-328.
[26] 李淼,王永香,孟谨,等. HPLC法测定金银花中新绿原酸等8中成分的量[J]. 中草药,2014,45(7):1 006-1 010.
[27] YOSHIMOTO M,YAHARA S,OKUNO S,et al. Antimutagenicity of mono-,di-,and tricaffeoylquinic acids derivatives isolated from sweet potato(Ipomoea batatas L.)leaf[J]. Bioscience biotechnology biochemistry,2002,66(11):2336.
[28] KIM H J,LEE Y S. Identification of new dicaffeoylquinic acids from Chrysanthemum morifolium and their antioxidant activities[J]. Planta Medica,2005,71(9):871-876.
[29] 万会达,蔡亚,校秋燕. 甜菊糖的酶法改性及其生物活性研究进展[J]. 中国食品添加剂,2011:188-196.
[30] 苑振忠. 发展甜菊糖前景极其广阔[J]. 中国种业,2004(4):12.
[31] 胡静,陈育如,魏霞,等. 高产环糊精葡萄糖基转移酶的枯草芽孢杆菌选育产酶与酶学特性[J]. 食品与生物技术学报,2008,27(4):97-102.
[32] DE OLIVEIRA B H,PACKER J F,CHIMELLI M,et al. Enzymatic modification of stevioside by cell-free extract of Gibberella fujikuroi[J]. Journal of biotechnology,2007,131(1):92-96.
[33] 刘虎,陈育如,姜中玉. 一株快速转化甜菊苷的细菌鉴定、产酶及转化特性[J]. 微生物学报,2010,50(6):885-890.
[34] 陈育如,刘虎,姜中玉,等. 一种提高甜菊糖甜质的方法:ZL200910036066.5[P]. 2011-11-16.
[35] URBAN J D,CARAKOSTAS M C,BRUSICK D J. Steviol glycosidesafety:is the genotoxicity database sufficient[J]. Food and chemical toxicology,2013,51:386-390.
[36] JAN M C. Geuns 甜菊与甜菊糖苷[M]. 欧仕益,彭喜春,周华,等译. 北京:中国轻工业出版社,2013.
[37] MISHRA P K,SINGH R,KUMAR U,et al. Stevia rebaudiana -a magical sweetener[J]. Global J Biotechnology Biochemistry,2010,5(1):62-74.
[38] 陈育如,刘虎,姜中玉,等. 一种异甜菊醇或其衍生物的超分子组合物及制备方法:ZL 200910033424.7[P]. 2009-10-03.
[39] 陈育如,张怡斐,马迎迎,等. 一种以甜叶菊同时制备总咖啡酰奎尼酸和甜菊糖的方法:ZL 20121005562.3[P]. 2012-08-05.
[40] 陈育如,张怡斐,张卫明,等. 一种甜叶菊黑茶的加工方法:CN 201310005241.0[P]. 2013-09-26.
[41] 陈育如,张怡斐. 一种甜叶菊保健酒及其配制方法:ZL 201310005152.6[P]. 2013-10-05.
[42] 谱赛科公司. 谱赛科2015年年度财务报告(英文)[R]. 马来西亚,吉隆波:谱赛拜公司,2015.


Last Update: 2016-06-30