|Table of Contents|

HCV Epidemiological Survey of Voluntary Blood Donors in Jiangsu Area(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2016年02期
Page:
73-
Research Field:
生命科学
Publishing date:

Info

Title:
HCV Epidemiological Survey of Voluntary Blood Donors in Jiangsu Area
Author(s):
Xu Jianfeng; Zhu Shaowen; Jiang Nizhen; Hu Wenjia; Tang Xinyi; Wang Jinhua; Zhu Shengjiang; Lin Hong
Blood Center of Jiangsu Province，Nanjing 210042，China
Keywords:
HCV; voluntary blood donors; genotype
PACS:
R446.1
DOI:
10.3969/j.issn.1001-4616.2016.02.014
Abstract:
To study the prevalence of HCV infection and its epidemiological characteristics in Jiangsu area. 157，119 health blood donation of blood samples in blood center of Jiangsu Province from the year 2013 to 2014 anti HCV ELISA double reagent detection and HIV，HBV and HCV6-mixed like nucleic acid detection，the HCV RNA positive samples were detected by quantitative PCR method to determine the titer of virus；HCV RNA positive samples were nested PCR amplified fragments of the core area，according to the analysis of the gene sequencing results. Analysis of HCV genotype distribution and correlation with sex and age. A total of 347 cases of anti-HCV reactive specimens were detected，the positive rate was 0.22%. RNA HCV positive samples were not detected in the anti-HCV negative and -HCV positive samples by nucleic acid detection，and 46 cases of RNA positive samples were 125 cases of HCV positive samples，the positive rate was 36.8%. Nested PCR amplification of HCV RNA positive samples and sequencing and typing of 36 cases. Genotypes were 1a（2.6%），1B（74.4%），2A（10.2%），3b（5.1%），6a（5.1%）and 6N（2.8%）four genotypes and six kinds of genotypes，4 and 5 were not found. The proportion of type 2 and type 1 in the male group was significantly higher than that in the female group，but the difference was not statistically significant；the difference was statistically significant between the type 1，2 and type 3，6. The positive rate of anti -HCV in blood donors in Jiangsu area was decreased，and the infection of HCV was not correlated with the degree of gender and occupation education. However，there was a significant difference between genotype and age and occupation，and the genotype of HCV was 1b.

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Last Update: 2016-06-30