|Table of Contents|

Relative Electrical Impedance Variation Based Temperature MonitoringTechnology for High Intensity Focused Ultrasound Therapy(PDF)

《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2018年02期
Page:
39-
Research Field:
·物理学·
Publishing date:

Info

Title:
Relative Electrical Impedance Variation Based Temperature MonitoringTechnology for High Intensity Focused Ultrasound Therapy
Author(s):
Ding HepingSu HuidanMa QingyuGuo Gepu
School of Physics and Technology,Nanjing Normal University,Nanjing 210023,China
Keywords:
high intensity focused ultrasoundrelative electrical impedance variationfocal conductivity distributiontemperature monitoring
PACS:
O426.2
DOI:
10.3969/j.issn.1001-4616.2018.02.008
Abstract:
High intensity focused ultrasound(HIFU)can kill the tumor cells with the acousto-thermo-coagulation effects in the focal region,and it is considered to be the noninvasive technology for therapy. Based on the principle of acoustic transmission for HIFU,a composite model of HIFU therapy and electrical impedance measurement is established. Numerical studies for the distributions of the acoustic,temperature and conductivity fields in the focal region are conducted and the relative variations of the electrical impedance of the model are also achieved. It is proved that,for a fixed acoustic power,the relative impedance variation(RIV)shows a linear relationship with the treatment time and the rate of RIV increases linearly with the increase of the acoustic power. With the experimental setup,the measurements of the electrical impedance of the model are performed during the HIFU therapy,and good agreements to the simulation results are achieved. The favorable results verify the feasibility of noninvasive temperature monitoring using the RIV and also provide a new method for efficacy detection and dose control for HIFU therapy.

References:

[1] KENNEDY J E. High-intensity focused ultrasound in the treatment of solid tumours[J]. Nat Rev Cancer,2005,5:321-327.
[2]XING Y F,LU X C,PUS E C,et al. The Effect of high intensity focused ultrasound treatment on metastases in a Murine Melanoma model[J]. Biochem Biophys Res Commun,2008,375:645-650.
[3]JOLESZ F A,MCDANNOLD N. Current status and future potential of MRI-guided focused ultrasound surgery[J]. J Magn Reson Imag,2008,27:391-399.
[4]YE G,SMITH P P,NOBLE J A. Model-based ultrasound temperature visualization and following HIFU Exposure[J]. Ultrasound Med Biol,2010,36:234-249.
[5]QIAN Z W,YU J S,FEI X B,et al. Noninvasive temperature monitoring in HIFU clinical uses[J]. Int J Hyperthermia,2005,21:589-600.[6]DANIELS M J,VARGHESE T,MADSEN E L,et al. Non-invasive ultrasound-based temperature imaging for monitoring radiofrequency heating-phantom results[J]. Phys Med Biol,2007,52:4 827-4 843.
[7]MA Y,ZHANG D,GONG X F,et al. Noninvasive temperature estimation by detecting echo-strain change including thermal expansion[J]. Chin Phys,2007,16:2745-2751.
[8]ANAND A. Noninvasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound[D]. Seattle:University of Washington,2005.
[9]GABRIEL C,PENMAN A,GRANT E H. Electrical conductivity of tissue at frequencies below 1 MHz[J]. Phys Med Biol,2009,54:4863-4878.
[10]ZURBUCHEN U,HOLMER C,LEHMANN K S,et al. Determination of the temperature-dependent electric conductivity of liver tissue ex vivo and in vivo:importance for therapy planning for the radio frequency ablation of liver tumours[J]. Int J Hyperthermia,2010,26:26-33.
[11]蔡华,尤富生,史学涛,等. 兔离体新鲜肝组织的电阻抗温度特性研究[J]. 医疗卫生装备,2010,11:8-11.
[12]李发琪,张樯,杜永洪,等. 高强度聚焦超声治疗剂量对组织温升影响的研究[J]. 生物医学工程学杂志,2003,3:466-471.
[13]BORCEA L. Electrical impedance tomography[J]. Inverse problems,2002,18:R99-R136.
[14]BLACKSTOCK D T. Fundamentals of physical acoustics[M]. New York:John Wiley & Sons Inc,2000.
[15]范庭波. 高强度聚焦超声非线性声场和组织损伤形成的扫描模式比较研究[D]. 南京:南京大学,2012.
[16]PENNES H H. Analysis of tissue and arterial blood temperatures in the resting human forearm[J]. J Appl Physiol,1948,1:93-122.
[17]郭各朴,宿慧丹,丁鹤平,等. 基于电阻抗层析成像的高强度聚焦超声温度监测技术[J]. 物理学报,2017,66:164301.
[18]TAKEGAMI K,KANEKO Y,WATANABE T,et al. Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound[J]. Ultrasound Med Biol,2004,30:1419-1422.
[19]胡兵,姜立新,黄瑛. 用于高强度聚焦超声热消融的PAA模块:模块的制作及声学参数的测量[J]. 声学技术,2006,6:613-616.
[20]TAO C Y,GUO G P,MA Q Y,et al. Accurate acoustic power measurement for low intensity focused ultrasound using focal axial vibration velocity[J]. J App Phys,2017,122(1):014 901.
[21]宿慧丹,戴思捷,郭各朴,等. HIFU焦域的温度分布模拟及其疗效分析[J]. 南京师大学报(自然科学版),2017,40:144-150.
[22]SU H D,GUO G P,MA Q Y,et al. Noninvasive treatment efficacy monitoring and dose control for high intensity focused ultrasound therapy using relative electrical impedance variation[J]. Chinese Physics B,2017,26(5):054302.
[23]MYERS M R,SONESON J E. Temperature modes for nonlinear Gaussian beams[J]. Journal of the acoustical society of America,2009,126(1):425-433.
[24]SONESON J E,MYERS M R. Gaussian representation of high-intensity focused ultrasound beams[J]. Journal of the acoustical society of America,2007,122(5):2526-2531.

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Last Update: 2018-11-06