|Table of Contents|

LncRNAs and miRNAs from a ceRNA Network as a Signature CanImprove the Diagnosis and Prognosis of CESC Patients(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2020年04期
Page:
53-61
Research Field:
·生物学·
Publishing date:

Info

Title:
LncRNAs and miRNAs from a ceRNA Network as a Signature CanImprove the Diagnosis and Prognosis of CESC Patients
Author(s):
Zhu Peiwen1; Shi Xuejia2; Qin Shijie2; Liao Min1; Ma Fei2
(1.School of Plant Protection,Anhui Agricultural University,Hefei 230036,China)(2.School of Life Sciences,Nanjing Normal University,Nanjing 210023,China)
Keywords:
cervical squamous cell carcinoma(CESC); lncRNA; miRNA; ceRNA network; prognostic factor
PACS:
R737
DOI:
10.3969/j.issn.1001-4616.2020.04.009
Abstract:
Cervical squamous cell carcinoma(CESC)seriously harms women’s health worldwide. Therefore,it is of great value to find new diagnostic and prognostic factors to improve the prevention and treatment of CESC. To further screen out effectively biomarkers for promoting the diagnosis and prognosis of CESC patients,it was here systematically investigated the expression landscapes of lncRNAs,miRNAs and mRNAs from The Cancer Genome Atlas(TCGA). In this work,it was firstly identified 25 lncRNAs,14 miRNAs and 371 genes associated with CESC patients’ survival. Secondly,it constructed a survival-related lncRNA-miRNA-mRNA ceRNA network. Thirdly,it was discovered that 2 lncRNAs(TP73-AS1 and CASC15),3 miRNAs(hsa-MiR-142-3p,hsa-MiR-128-3p and hsa-MiR-642a-5p)could be used as promising diagnostic and prognostic biomarkers for CESC,in particular highly expressed TP73-AS1 and CASC15 could act as poor prognostic factors,whereas highly expressed hsa-MiR-142-3p,hsa-MiR-128-3p and hsa-MiR-642a-5p could serve as good prognostic factors for the survival of CESC patients. Finally,our results demonstrated that a signature containing TP73-AS1,CASC15,hsa-MiR-142-3p,hsa-MiR-128-3p and hsa-MiR-642a-5p could significantly facilitate the prognosis and credibility of CESC patients. Taken together,our present study identified several novel diagnostic and prognostic factors for CESC patients,and revealed a potential mechanism of facilitating the survival of CESC patients.

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Last Update: 2020-11-15