|Table of Contents|

FEN1 Inhibitor SC13 Reverses the Drug Resistance of MCF-7/ADR Cells(PDF)

《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2024年04期
Page:
77-85
Research Field:
生物学
Publishing date:

Info

Title:
FEN1 Inhibitor SC13 Reverses the Drug Resistance of MCF-7/ADR Cells
Author(s):
Liu JieWang YuanyuanGuo ZhigangHe Lingfeng
(School of Life Sciences,Nanjing Normal University,Jiangsu Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210023,China)
Keywords:
breast cancerFEN1adriamycintumor treatmentchemoresistance
PACS:
R3F36H
DOI:
10.3969/j.issn.1001-4616.2024.04.009
Abstract:
The development of multidrug resistance(MDR)in cancer cells during chemotherapy poses a significant challenge in the clinical treatment of breast cancer. One of the main contributors to drug resistance is the robust DNA damage repair capability of tumor cells. The research had revealed that Flap endonuclease 1(FEN1),a core protein involved in the base excision repair(BER)pathway,was highly expressed in adriamycin-resistant breast cancer cells. Moreover,the study found that the FEN1 inhibitor SC13 significantly enhanced the sensitivity of MCF-7/ADR cells to adriamycin. While the precise mechanism of action was not yet fully understood,it was hypothesized that the enhanced sensitivity of MCF-7/ADR cells may be attributed to the activation of potent antitumor responses mediated by the cGAS-STING-NFκB signaling pathways.

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Last Update: 2024-12-15