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Numerical Studies on Temperature Distribution Analysis and Treatment Efficacy Evaluation for High Intensity Focused Ultrasound Therapy(PDF)


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Numerical Studies on Temperature Distribution Analysis and Treatment Efficacy Evaluation for High Intensity Focused Ultrasound Therapy
Su Huidan1Dai Sijie2Guo Gepu1Ma Qingyu1
(1.School of Physics and Technology,Nanjing Normal University,Nanjing 210023,China)(2.Honors College,Nanjing Normal University,Nanjing 210023,China)
HIFU therapystructure coefficienttemperature distributionefficacy evaluation
High intensity focused ultrasound(HIFU)is a non-invasive therapeutic medical treatment modality,which can destroy tumor tissues without damaging to the surrounding normal tissues and has less possibility of cancer metastasis. The key issue of accurate HIFU therapeutic dosage control is how to monitor the efficacy in the process of HIFU treatment. Based on HIFU localized tissue heating,the model of HIFU treatment is established using the finite element method(FEM),and the numerical simulations of the acoustic and temperature fields at HIFU focal region are developed. The influences of transducer parameters,acoustic power and treatment time on temperature distribution at the focal region are discovered. It is proved that,with the increasing treatment time,the ellipsoidal focal region forms gradually with a rising temperature distribution. Once reaching HIFU treatment efficacy,the temperature of the focal region(in radial±0.4 mm)reaches 343 K(70 ℃),with the decrease of the structure coefficient(radius/focal length)of the transducer,the required treatment time increases,producing a narrower ellipsoidal focal region with an enhanced ratio between the radial width and axial width. Therefore,the simulations of temperature field for the transducer with a known structure coefficient in this study provide a new method for temperature estimation,efficacy evaluation and dose control in the HIFU therapy.


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