|Table of Contents|

Angiotensin Ⅱ Promotes the Migration of Breast Cancer Cells(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2018年01期
Page:
83-
Research Field:
·生命科学·
Publishing date:

Info

Title:
Angiotensin Ⅱ Promotes the Migration of Breast Cancer Cells
Author(s):
Cao Lingsen; Shen Wei; Cao Xiangrong
School of Life Sciences,Nanjing Normal University,Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210023,China
Keywords:
AngⅡ; uPA; breast cancer cell
PACS:
Q28
DOI:
10.3969/j.issn.1001-4616.2018.01.015
Abstract:
Breast cancer is a high incidence and malignant tumor in women. The invasion and metastasis are the major reasons that leading to the death of patients. It is of great significance to study the factors and biomarkers associated with cancer metastasis. In this study,the migration of breast cancer cells MDA-MB-231 treated with the angiotensin Ⅱ(AngⅡ)was enhanced. The AngⅡ significantly stimulated the expression of uPA(2.97 times)and uPAR in MDA-MB-231 cells by the Q-PCR measurement. Therefore,the AngⅡ could stimulate the expression of uPA and uPAR in breast cancer cells,which maybe one of the reasons promoting breast cancer cell migration by AngⅡ

References:

[1] KINOSHITA J,FUSHIDA S,HARADA S,et al. Local angiotensin Ⅱ-generation in human gastric cancer:correlation with tumor progression through the activation of ERK1/2,NF-kappaB and surviving[J]. Int J Oncol,2009,34(6):1 573-1 582.
[2]PUDDEFOOT J R,UDEOZO U K I,BARKER S,et al. The role of angiotensin Ⅱ in the regulation of breast cancer cell adhesion and invasion[J]. Endocrine-related cancer,2006,13:895-903.
[3]SUGANUMA T,INO K,SHIBATA K,et al. Functional expression of the angiotensin Ⅱ type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion,angiogenesis,and peritoneal dissemination[J]. Clin Cancer Res,2005,11(7):2 686-2 694.
[4]OH E,KIM J Y,CHO Y,et al. Over-expression of angiotensin Ⅱ type 1 receptor in breast cancer cells induces epithelial-mesenchymal transition and promotes tumor growth and angiogenesis[J]. Biochim Biophys Acta,2016,1863(6 Pt A):1 071-1 081.
[5]FUJIHARA S,MORISHITA A,OGAWA K,et al. The angiotensin Ⅱ type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKa/mTOR pathway in vitro and in vivo[J]. Oncotarget,2017,8(5):8 536-8 549.
[6]CHEN X,MENG Q,ZHAO Y,et al. Angiotensin Ⅱ type 1 receptor antagonists inhibit cell proliferation and angiogenesis in breast cancer[J]. Cancer Lett,2013,328(2):318-324.
[7]GUO R,GU J,ZHANG Z,et al. MicroRNA-410 functions as a tumor suppressor by targeting angiotensin Ⅱ type 1 receptor in pancreatic cancer[J]. IUBMB Life,2015,67(1):42-53.
[8]FOEKENS J A,PETERS H A,LOOK M P,et al. The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients[J]. Cancer Res,2000,60(3):636-643.
[9]王学谦,林洪生. uPA/uPAR与恶性肿瘤关系的研究进展[J]. 医学研究杂志,2016,45(9):16-17.
[10]SALEHI A H,XANTHOUDAKIS S,BARKER P A. NRAGE,a p75 neurotrophin receptor interacting protein,induces caspase activation and cell death through a JNK dependent mitochondrial pathway[J]. J Biol Chem,2002,277(50):48 043-48 050.
[11]CHU,C S,CHU C S,XUE B,et al. NRAGE suppresses metastasis of melanoma and pancreatic cancer in vitro and in vivo[J]. Cancer Lett,2007,250(2):268-275.
[12]STILLFRIED G E,SAUNDERS D N,RANSON M. Plasminogen binding and activation at the breast cancer cell surface:the integral role of urokinase activity[J]. Breast Cancer Res,2007,9(1):R14.
[13]WANG Y X,MARTIN-MCNULTY B,FREAY A D,et al. Angiotensin Ⅱ increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice[J]. Am J Pathol,2001,159(4):1 455-1 464.
[14]RODRIGUES-FERREIRA S R,ABDELKARIM M,DILLENBURG-PILLA P,et al. Angiotensin Ⅱ facilitates breast cancer cell migration and metastasis[J]. PLoS ONE,2012,7(4):e35667.
[15]PUDDEFOOT J R,UDEOZO U K I,BARKER S,et al. The role of angiotensin Ⅱ in the regulation of breast cancer cell adhesion and invasion[J]. Endocrine-related cancer,2006,13:895-903.
[16]PENAFUERTE C A,GAGNON B,SIROIS J,et al. Identification of neutrophil-derived proteases and angiotensin Ⅱ as biomarkers of cancer cachexia[J]. Br J Cancer,2016,114(6):680-687.
[17]SHIMIZU D,KANDA M,SUGIMOTO H,et al. NRAGE promotes the malignant phenotype of hepatocellular carcinoma[J]. Oncology Lett,2016,11:1 847-1 854.

Memo

Memo:
-
Last Update: 2018-03-31