|Table of Contents|

Injectable pH-sensitive Antibacterial Hydrogel Based onAldehyde-Guar and Tobramycin and Its Properties(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2020年02期
Page:
34-42
Research Field:
·化学·
Publishing date:

Info

Title:
Injectable pH-sensitive Antibacterial Hydrogel Based onAldehyde-Guar and Tobramycin and Its Properties
Author(s):
Cheng Miao1; Wang Huaisheng1; Cheng Shuang2
(1.College of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252000,China)(2.College of Agriculture,Liaocheng University,Liaocheng 252000,China)
Keywords:
aldehyde-guar; tobramycin; composite hydrogel; rheological characteristics; injectable; self-healing; pH-sensitive; antibacterial activity
PACS:
TS201.7
DOI:
10.3969/j.issn.1001-4616.2020.02.007
Abstract:
Microbial infection is one of the underlying causes of death in the world,which imposes the threat to the public health. To fight against infection and overcome the resistance of microbial has drawn great research interest in materials science and engineering. Polymer hydrogels based on antibiotics have been highly pursued due to the excellent antimicrobial ability,biocompatibility,biodegradability and negligible toxicity. The stimuli-responsive characteristic,bio-inspired functions and rheological properties of the hydrogel which was facilely prepared simply by fabricating aldehyde-guar gum and tobramycin in situ deposition,with its antibacterial ability against E.coli and cytocompatiblility were extensively uated in this paper. The results reveal that the smart injectable self-healing hydrogel prepared through the dynamic Schiff base possesses satisfactory rheological properties and sufficient drug loading capability,which presents a self-healing acid sensitive tobramycin sustained release profile after inject in situ and can be used as a practical platform for drug-delivery with distinct applications of antimicrobial. The composite hydrogel is exceptionally propitious to accelerate treatment potential of infection for its porous microstructure,it also is the appropriate biocarrier for cell,drug and macromolecules delivery in the biomedical field.

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Last Update: 2020-05-15