[1]高伟,许龙兵,陈龙,等.免疫初乳对大鼠血液某些生理指标和激素水平的影响[J].南京师大学报(自然科学版),2009,32(03):84-87.
　Gao Wei,Xu Longbing,Chen Long.Effect of Immune Colostrums on Some Blood Physiological Indices and Hormone Levels in Rats[J].Journal of Nanjing Normal University(Natural Science Edition),2009,32(03):84-87.
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免疫初乳对大鼠血液某些生理指标和激素水平的影响()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第32卷
期数:
2009年03期
页码:
84-87
栏目:
生命科学
出版日期:
2009-09-30

文章信息/Info

Title:
Effect of Immune Colostrums on Some Blood Physiological Indices and Hormone Levels in Rats
作者:
高伟;许龙兵;陈龙;
南京师范大学生命科学学院, 江苏省分子医学生物技术重点实验室, 江苏省生物医药功能材料工程研究中心, 江苏南京210046
Author(s):
Gao Wei; Xu Longbing; Chen Long
School of Life Sciences,Nanjing Normal University,Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology,Jiangsu Engineering Research Center for Bio-medical Function Materials,Nanjing 210046,China
关键词:
免疫初乳;  大鼠;  血液;  生理指标;  激素水平
Keywords:
imm une co lostrum;  rat;  blood;  phys io log ical index;  horm one level
分类号:
R151
摘要:
24只健康成年SD大鼠, 雌雄对半, 随机分成对照组( C组) 、普通初乳组( NC组) 、免疫初乳组( IC组), 每组8只. NC和IC组每天分别灌服普通初乳和免疫初乳( 1 mL /100 g 体重), C 组灌服生理盐水. 连续6 d. 在第 6天观察了灌胃免疫初乳后大鼠血液某些生理指标和激素水平的变化, 探讨免疫初乳在参与机体生理活动和内分泌功能活动过程中的作用. 结果显示, 在整个实验期内, IC组大鼠血液中性粒细胞显著高于C、NC 组; NC 和IC 组大鼠血浆中Ins水平极显著高于对照组; IC 组大鼠T3 水平显著高于对照组; 然而, 在整个实验期, 大鼠血浆 T4、IL- 2水平各组间无显著差异. 提示免疫初乳可提高正常机体非特异性免疫功能, 促进机体代谢激素的分泌, 但对细胞免疫没有明显效应.
Abstract:
Tw enty- four healthy SD rats w ith ha lf of fem a le and m a le w ere chosen and random ly d iv ided into a contro l g roup ( g roup C) , a norm al co lo sturm group ( group NC) and a immune co lostrum s group ( g roup IC) . 8 ra ts in each g roup. Ra ts in groups NC and IC w ere orally g iven 1 mL /100 g BW once a day during 6 days, norm a l co lostrum or immune co lostrum, respective ly. The rats in g roups C we re rece ived physio log ic saline at the sam e dose and frequency. A -f ter exper iment, Physiolog ica l index and horm one lev els in p lasm a we re tested to lea rn the imm une co lo strum s action in physio log ica l and endocr ine. The resu lts showed that dur ing thew ho le exper im enta l per iod, b lood neutrophilic granulocy tes in group IC w ere dram atically higher than tha t in groups C and NC. Plasma Ins level in g roups NC and IC, and T3 level in group IC, w ere significantly h igher as com pared w ith contro l g roup. Plasm aT4 and IL-2 leve ls w ere near am ong three g roups. It suggests that the imm une co lostrum s can enhance non- spec ific imm une function, and prom ote the excretion of m etabo lism horm ones, but take no obv ious e ffects on ce llular immunity in the body.

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备注/Memo

备注/Memo:
基金项目: 国家” 十五“奶业重大科技专项( 2002BA518A12)、江苏省“ 十五”攻关项目( BE2002302 ).
通讯联系人: 陈 龙, 博士, 教授, 研究方向: 免疫生理学与生物化学. E-m ail: lchen@ n jnu. edu. cn
更新日期/Last Update: 2013-04-23