[1]章康宁,王佳伟,马青玉.双频激励超声造影剂微气泡差频特性的理论和实验研究[J].南京师大学报(自然科学版),2015,38(02):30.
　Zhang Kangning,Wang Jiawei,Ma Qingyu.Theoretical and Experimental Study on Contrast Agent Microbubbles Induced Difference Frequency Ultrasound with Dual-Frequency Excitation[J].Journal of Nanjing Normal University(Natural Science Edition),2015,38(02):30.
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双频激励超声造影剂微气泡差频特性的理论和实验研究()
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《南京师大学报》（自然科学版）[ISSN:1001-4616/CN:32-1239/N]

卷:
第38卷
期数:
2015年02期
页码:
30
栏目:
物理学
出版日期:
2015-06-30

文章信息/Info

Title:
Theoretical and Experimental Study on Contrast Agent Microbubbles Induced Difference Frequency Ultrasound with Dual-Frequency Excitation
作者:
章康宁1; 王佳伟2; 马青玉2
(1.南京邮电大学通信与信息工程学院,江苏 南京 210023) (2.南京师范大学物理科学与技术学院,江苏 南京 210023)
Author(s):
Zhang Kangning1; Wang Jiawei2; Ma Qingyu2
(1.College of Telecommunications and Information Engineering,Nanjing University of Posts and Telecommunications,Nanjing 210023,China) (2.School of Physics and Technology,Nanjing Normal University,Nanjing 210023,China)
关键词:
差频超声; 超声造影剂; 双频激励; 参量阵效应; Runge-Kutta算法
Keywords:
difference-frequency ultrasound; contrast agents; dual-frequency excitation; parametric effect; Runge-Kutta algorithm
分类号:
O426.1
文献标志码:
A
摘要:
超声参量阵效应产生的差频超声由于具有较小的衰减系数,能够有效提高传播深度而实现深层组织的超声成像. 本文基于RPNNP方程,对双频激励超声造影剂微气泡所产生差频信号声压进行了理论推导,并用Runge-Kutta算法进行了数值模拟,对差频信号产生的条件包括激励声压、超声频率和气泡大小等进行了优化,同时用不同参数的双频信号辐射造影剂实现差频超声激发的实验研究,理论与实验结果均表明当双频信号的频率差接近气泡的共振频率时可以大幅度提高差频信号的声压(28 dB),获得高信噪比的差频信号,本研究为双频超声激励下造影剂差频成像的实际应用提供了研究基础.
Abstract:
The ultrasound image depth can be enhanced using the Difference-frequency(DF)ultrasound generated by the parametric effect with low attenuation coefficient. In this paper,a theoretical derivation of DF signal from contrast agents with dual-frequency excitation is proposed based on the solution of the RPNNP equation,and nμmerical simulations are performed using the Runge-Kutta algorithm. The optimization of the DF generation is discussed associated with the excite pressure,frequency difference and microbubble size and the dual-frequency excitation experiments are performed for DF geration. The favorable results demonstrate that the optimized DF ultrasound can be achieved with a pressure enhancement as high as 28 dB when the difference frequency is close to the resonance frequency of the contrast agents with improved signal-to-noise ratio,which provide the basis for potential application of DF ultrasound in medical imaging.

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备注/Memo

备注/Memo:
收稿日期:2014-11-06.
基金项目:国家自然科学基金(11274176、11474166)、江苏高校优势学科建设工程资助项目.
通讯联系人:马青玉,教授,研究方向:声学、电子信息. E-mail:maqingyu@njnu. edu. Cn
更新日期/Last Update: 2015-06-30