[1]宿慧丹,戴思捷,郭各朴,等.HIFU焦域的温度分布模拟及其疗效分析[J].南京师范大学学报(自然科学版),2017,40(01):144.[doi:10.3969/j.issn.1001-4616.2017.01.021]
　Su Huidan,Dai Sijie,Guo Gepu,et al.Numerical Studies on Temperature Distribution Analysis and Treatment Efficacy Evaluation for High Intensity Focused Ultrasound Therapy[J].Journal of Nanjing Normal University(Natural Science Edition),2017,40(01):144.[doi:10.3969/j.issn.1001-4616.2017.01.021]
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HIFU焦域的温度分布模拟及其疗效分析()
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《南京师范大学学报》（自然科学版）[ISSN:1001-4616/CN:32-1239/N]

卷:
第40卷
期数:
2017年01期
页码:
144
栏目:
·物理学·
出版日期:
2017-03-31

文章信息/Info

Title:
Numerical Studies on Temperature Distribution Analysis and Treatment Efficacy Evaluation for High Intensity Focused Ultrasound Therapy
文章编号:
1001-4616(2017)01-0144-07
作者:
宿慧丹1; 戴思捷2; 郭各朴1; 马青玉1
(1.南京师范大学物理科学与技术学院,江苏 南京 210023)(2.南京师范大学强化培养学院,江苏 南京 210023)
Author(s):
Su Huidan1; Dai Sijie2; Guo Gepu1; Ma Qingyu1
(1.School of Physics and Technology,Nanjing Normal University,Nanjing 210023,China)(2.Honors College,Nanjing Normal University,Nanjing 210023,China)
关键词:
HIFU治疗; 结构系数; 温度分布; 疗效评估
Keywords:
HIFU therapy; structure coefficient; temperature distribution; efficacy evaluation
分类号:
O426.2
DOI:
10.3969/j.issn.1001-4616.2017.01.021
文献标志码:
A
摘要:
高强度聚焦超声(HIFU)是一种非侵入性、对正常组织无损伤且不易引起癌细胞转移的肿瘤治疗手段,对其治疗过程中的疗效以及肿瘤周围正常组织破坏情况的监测是实现HIFU治疗剂量精准控制的关键. 本文首先从HIFU局部组织加热出发,建立了HIFU治疗系统模型,利用有限元数值模拟了HIFU焦域的声场以及温度场分布,并研究了换能器参数、超声功率、治疗时间对焦域温度分布的影响. 结果表明,随着治疗时间的增长,焦点温度上升,逐渐形成椭球状的焦域; 在达到治疗疗效时,即焦域径向±0.4 mm椭球范围内的组织温度达到了343 K(70 ℃)时,随着换能器结构系数(半径/焦距)的减小,所需要的治疗时间增长,所形成的焦域不断扩大,其轴向宽度与径向宽度比值增大,焦域变得细长,焦点处的温度逐渐降低. 本研究对已知结构系数的聚焦换能器的焦域温度场仿真,可以为HIFU治疗中的温度估计和监控提供新方法,也可为疗效评估和剂量控制提供新技术.
Abstract:
High intensity focused ultrasound(HIFU)is a non-invasive therapeutic medical treatment modality,which can destroy tumor tissues without damaging to the surrounding normal tissues and has less possibility of cancer metastasis. The key issue of accurate HIFU therapeutic dosage control is how to monitor the efficacy in the process of HIFU treatment. Based on HIFU localized tissue heating,the model of HIFU treatment is established using the finite element method(FEM),and the numerical simulations of the acoustic and temperature fields at HIFU focal region are developed. The influences of transducer parameters,acoustic power and treatment time on temperature distribution at the focal region are discovered. It is proved that,with the increasing treatment time,the ellipsoidal focal region forms gradually with a rising temperature distribution. Once reaching HIFU treatment efficacy,the temperature of the focal region(in radial±0.4 mm)reaches 343 K(70 ℃),with the decrease of the structure coefficient(radius/focal length)of the transducer,the required treatment time increases,producing a narrower ellipsoidal focal region with an enhanced ratio between the radial width and axial width. Therefore,the simulations of temperature field for the transducer with a known structure coefficient in this study provide a new method for temperature estimation,efficacy evaluation and dose control in the HIFU therapy.

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备注/Memo

备注/Memo:
收稿日期:2016-09-29.
基金项目:国家自然科学基金(11604156、11474166)、江苏省自然科学基金(BK20161013)、中国博士后科学基金(2016M591874)、江苏高校优势学科建设项目.
通讯联系人:马青玉,博士,教授,研究方向:电子技术、信息处理和声学. E-mail:maqingyu@njnu.edu.cn
更新日期/Last Update: 1900-01-01