[1]周 莉,赵光辉,周 林,等.一种水溶性酞菁纳米晶的制备及光敏活性研究[J].南京师范大学学报(自然科学版),2017,40(03):118.[doi:10.3969/j.issn.1001-4616.2017.03.017]
　Zhou Li,Zhao Guanghui,Zhou Lin,et al.Preparation and Photodynamic Activity of a Water-SolublePhthalocyanine Nanoparticle[J].Journal of Nanjing Normal University(Natural Science Edition),2017,40(03):118.[doi:10.3969/j.issn.1001-4616.2017.03.017]
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一种水溶性酞菁纳米晶的制备及光敏活性研究()
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《南京师范大学学报》（自然科学版）[ISSN:1001-4616/CN:32-1239/N]

卷:
第40卷
期数:
2017年03期
页码:
118
栏目:
·化学·
出版日期:
2017-09-30

文章信息/Info

Title:
Preparation and Photodynamic Activity of a Water-SolublePhthalocyanine Nanoparticle
文章编号:
1001-4616(2017)03-0118-05
作者:
周 莉1; 赵光辉1; 周 林2; 魏少华2
(1.南京航空航天大学材料科学与技术学院,江苏 南京 211106)(2.南京师范大学化学与材料科学学院,江苏 南京 210046)
Author(s):
Zhou Li1; Zhao Guanghui1; Zhou Lin2; Wei Shaohua2
(1.College of Material Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China)(2.School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210046,China)
关键词:
光动力疗法; 锌酞菁; 纳米晶; 光敏抗肿瘤活性
Keywords:
photodynamic therapy; zinc phthalocyanine; nanocrystalline; photosensitive anticancer activity
分类号:
O644.1
DOI:
10.3969/j.issn.1001-4616.2017.03.017
文献标志码:
A
摘要:
通过“再沉淀法”将一种疏水性的锌酞菁(2(3),9(10),16(17),23(24)-四-(((2-(三苯甲基-氨基)乙胺基)甲基)苯氧基)锌酞菁(Ⅱ),NNZnPc)转变成一种水溶性的酞菁纳米晶(NNZnPc-NP),该酞菁纳米晶符合光动力疗法(Photodynamic therapy,PDT)对药物运载的需求. 通过透射电镜(TEM)、紫外-可见分光光度计(UV-Vis)、倒置荧光显微镜研究和表征了该酞菁纳米晶的表面形貌、稳定性、单线态氧产生能力以及光敏抗肿瘤活性. 所制备的NNZnPc-NP颗粒粒径均一、分散性好、在水溶液中能稳定存在,且有较高的单线态氧(1O2)产生效率及抗光漂白的能力. 体外抗肿瘤实验结果表明,可见光照射下NNZnPc-NP可有效杀灭宫颈癌细胞(HeLa),有较好的应用潜力.
Abstract:
A novel water soluble nanocrystalline phthalocyanine(NNZnPc-NP)was prepared using reprecipitation method. The surface morphology,stability,singlet oxygen generation ability and photosensitive anticancer activity of it were studied by transmission electron microscopy(TEM),UV-Vis spectrophotometer and inverted fluorescence microscope. The results showed that the particle size of NNZnPc-NP is uniform,the dispersion is good,and it can be stable in aqueous solution. Besides,it also exhibits excellent singlet oxygen generation ability and photostability. The in vitro anticancer experiment results confirm that NNZnPc-NP can efficiently kill HeLa cells under the visible light irradiation. The above results indicate NNZnPc has good potential to be used as clinical photosensitizer for PDT.

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相似文献/References:

[1]卢珊,魏少华,周家宏,等.β-四(羧基苯氧基)锌酞菁配合物的合成与光谱性质研究[J].南京师范大学学报(自然科学版),2006,29(01):59.
　Lu Shan~.Study on Synthesis and Spectral Properties of β-Tetra-Carboxyphenyloxy Substituted Zinc Phthalocyanine[J].Journal of Nanjing Normal University(Natural Science Edition),2006,29(03):59.

备注/Memo

备注/Memo:
收稿日期:2017-03-20.
基金项目:教师教学能力提升研究课题(90YAJ16018)、 江苏省优势学科建设工程资助项目.
通讯联系人:魏少华,教授,研究方向:光敏剂的结构设计、合成和光敏活性研究. E-mail:shwei@njnu.edu.cn
更新日期/Last Update: 2017-09-30