[1]刘振东,杨海芮,贾 薇,等.食药用真菌天然组分的抗肿瘤研究[J].南京师范大学学报(自然科学版),2018,41(01):108.[doi:10.3969/j.issn.1001-4616.2018.01.019]
　Liu Zhendong,Yang Hairui,Jia Wei,et al.The Antitumor Activity of Natural Components of Edible and Medicinal Fungi[J].Journal of Nanjing Normal University(Natural Science Edition),2018,41(01):108.[doi:10.3969/j.issn.1001-4616.2018.01.019]
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食药用真菌天然组分的抗肿瘤研究()
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《南京师范大学学报》（自然科学版）[ISSN:1001-4616/CN:32-1239/N]

卷:
第41卷
期数:
2018年01期
页码:
108
栏目:
·生命科学·
出版日期:
2018-03-31

文章信息/Info

Title:
The Antitumor Activity of Natural Components of Edible and Medicinal Fungi
文章编号:
1001-4616(2018)01-0108-04
作者:
刘振东1; 杨海芮2; 3; 贾 薇2; 薛 蓓1; 李 梁1; 汪雯翰2
(1.西藏农牧学院食品科学学院,西藏 林芝 860000)(2.上海市农业科学院食用菌研究所,农业部南方食用菌资源利用重点实验室,国家食用菌工程技术研究中心,国家食用菌加工技术研发分中心,上海市农业遗传育种重点开放实验室,上海 201403)(3.上海药明康德新药开发有限公司,上海 200131)
Author(s):
Liu Zhendong1; Yang Hairui2; 3; Jia Wei2; Xue Bei1; Li Liang1; Wang Wenhan2
(1.Xi Zang Agriculture and Animal Husbandry College,Linzhi 860000,China)(2.Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,Key Laboratory of Edible Fungi Resources and Utilization(South),Ministry of Agriculture,National Engineering R
关键词:
食药用真菌; 抗肿瘤; 细胞凋亡; 细胞自噬
Keywords:
edible and medicinal fungi; antitumor; apoptosis; autophagy
分类号:
S646
DOI:
10.3969/j.issn.1001-4616.2018.01.019
文献标志码:
A
摘要:
肿瘤是严重威胁人类健康和生命的疾病,其预防、诊治、机理等方面的研究已成为生物医学界关注的焦点. 食药用真菌在东方有着独特的经济和医药价值,其天然组分的活性研究更是深得广大研究者们的青睐,尤其是较好的抗肿瘤活性. 传统的化疗药物,普遍存在着毒副作用大、易耐药、复发率高等缺点,因此,从食药用真菌中提取高效、低毒、经济的天然活性抗肿瘤成分,探索其诱导细胞凋亡及细胞自噬的机制,用以研发新药将是生物医学工作者面临的挑战.
Abstract:
Cancer is a serious threat to human health and life. Researches on the mechanisms of prevention,diagnosis and treatment of cancer have become a focus in biomedical field. In the East,edible and medicinal fungi have unique economic and medicinal values,and their active components,especially the components with excellent anti-tumor activity,have attracted great attention of many researchers. Traditional chemotherapy drugs have many toxic side effects,such as easy to drug resistance,high recurrence rate and so on. Therefore,finding natural components with high efficiency and low toxicity from edible and medicinal fungi,and exploring the mechanisms of inducing apoptosis and autophagy,will become a challenge to biomedical researchers.

参考文献/References:

[1] LINDEQUIST U,NIEDERMEYER T H J,JüLICH W D. The pharmacological potential of mushrooms[J]. Evid-based Compl Alt,2005,2:285-299.
[2]梁一. 药用真菌杨树菇Agrocybe aegerita非多糖水溶性抗肿瘤组分研究[D]. 武汉:武汉大学,2010.
[3]李青. 桦褐孔菌多糖的提取、纯化及其抗肿瘤活性研究[D]. 青岛:青岛科技大学,2014.
[4]GUO L,XIE J,RUAN Y,et al. Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum[J]. Int Immunopharmacol,2009,9(10):1 175-1 182.
[5]杨全,胡旭光,王琦,等. 药用真菌桑黄菌丝体多糖抗肿瘤作用的研究[J]. 中国中药杂志,2006,20:1 713-1 715.
[6]NG T B. Peptides and proteins from fungi[J]. Peptides,2004,25:1 055-1 073.
[7]WONG J H,WANG H X,NG T B. Marmorin,a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus[J]. Appl Microbiol Biotechnol,2008,81(4):669-674.
[8]SUN Y Q,GUO T K,XI Y M,et al. Effects of AZT and RNA-protein complex(FA-2-b-beta)extracted from Liang Jin mushroom on apoptosis of gastric cancer cells[J]. World J Gastroenterol,2007,13(31):4 185-4 191.
[9]LEE T H,LEE C K,TSOU W L,et al. A new cytotoxic agent from soild-state fermented mycelium of antrodia camphorata[J]. Planta Med,2007,73(13):1 412-1 415.
[10]JI Z,TANG Q J,HAO R X,et al. Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3[J]. Oncol Lett,2011,2(3):565-570.
[11]王婷. 小分子三肽化合物LYRM03的抗肿瘤活性研究[D]. 上海:上海交通大学,2013.
[12]MENG L Z,XIE J,Lü G P,et al. A comparative study on immunomodulatory activity of polysaccharides from two official species of ganoderma(Lingzhi)[J]. Nutr Cancer,2014,66(7):1 124-1 131.
[13]LI W J,CHEN Y,NIE S P,et al. Ganoderma atrum polysaccharide induces antitumor activity via the mitochondrial apoptotic pathway related to activation of host immune response[J]. J Cell Biochem,2011,112:860-871.
[14]MIAO S,MAO X,PEI R,et al. Lepista sordida polysaccharide induces apoptosis of Hep-2 cancer cells via mitochondrial pathway[J]. Int J Biol Macromol,2013,61:97-101.
[15]YU C C,CHIANG P C,LU P H,et al. Antroquinonol,a natural ubiquinone derivative,induces a cross talk between apoptosis,autophagy and senescence in human pancreatic carcinoma cells[J]. J Nutr Biochem,2012,23(8):900-907.
[16]SINGH S V,SINGH K. Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research[J]. Carcinogenesis,2012,33(10):1 833-1 842.
[17]JOHNSON J J,BAILEY H H,MUKHTAR H. Green tea polyphenols for prostate cancer chemoprevention:a translational perspective[J]. Phytomedicine,2010,17(1):3-13.
[18]OLIVEIRA M,REIS F S,SOUSA D,et al. A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle[J]. Food Funct,2014,5(7):1 389-1 394.
[19]KUMAR S,GURU S K,PATHANIA A S,et al. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in Human Leukemia HL-60 Cells[J]. J Cell Biochem,2015,116(6):985-997.
[20]ZHOU Z W,LI X X,HE Z X,et al. Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells[J]. Drug Des Devel Ther,2015,12(9):1 511-1 554.

备注/Memo

备注/Memo:
收稿日期:2017-03-09.
基金项目:上海市自然科学基金(16ZR1431000)、上海市农业科学院青年人才成长计划(沪农青字(2016)第1-14号)、西藏自治区自然科学基金(2016ZR-NZ-03)、林芝市校地合作项目(lz-xd-04).
通讯联系人:汪雯翰,博士,副研究员,研究方向:天然产物分离提取及活性研究. E-mail:wangwenhan@seas.sh.cn
更新日期/Last Update: 2018-03-31