[1]丁 烨,姜 宇,张桠铭,等.硬骨鱼皮肤黏膜免疫分子及稳态维持的研究进展[J].南京师大学报(自然科学版),2025,48(05):55-65.[doi:10.3969/j.issn.1001-4616.2025.05.007]
　Ding Ye,Jiang Yu,Zhang Yaming,et al.Reviews on Skin Mucosal Immune Molecules and Homeostasis Maintenance of Teleost[J].Journal of Nanjing Normal University(Natural Science Edition),2025,48(05):55-65.[doi:10.3969/j.issn.1001-4616.2025.05.007]
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硬骨鱼皮肤黏膜免疫分子及稳态维持的研究进展()

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
48
期数:
2025年05期
页码:
55-65
栏目:
生物学
出版日期:
2025-10-20

文章信息/Info

Title:
Reviews on Skin Mucosal Immune Molecules and Homeostasis Maintenance of Teleost
文章编号:
1001-4616(2025)05-0055-11
作者:
丁 烨1; 姜 宇1; 张桠铭1; 2; 刘 惠1; 2; 王 帅1; 2; 董维兵3; 王 伟1; 2; 李雪洁1; 2
(1.大连海洋大学水产与生命学院,辽宁 大连 116023)
(2.大连海洋大学,辽宁省北方鱼类应用生物学及增养殖重点实验室,辽宁 大连 116023)
(3.辽宁师范大学生命科学学院,辽宁 大连 116029)
Author(s):
Ding Ye1; Jiang Yu1; Zhang Yaming1; 2; Liu Hui1; 2; Wang Shuai1; 2; Dong Weibing3; Wang Wei1; 2; Li Xuejie1; 2
(1.College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China)
(2.Dalian Ocean University, Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian 116023, China)
(3.College of Life Science, Liaoning Normal University, Dalian 116029, China)
关键词:
硬骨鱼; 黏膜免疫; 皮肤; 免疫分子; 稳态维持
Keywords:
teleost; mucosal immunity; skin; immune molecules; homeostasis maintenance
分类号:
Q175
DOI:
10.3969/j.issn.1001-4616.2025.05.007
文献标志码:
A
摘要:
硬骨鱼类的免疫系统与其他脊椎动物非常相似,主要在可溶性蛋白质、受体以及免疫细胞的参与下发挥作用. 这些可溶性的蛋白质在鱼类进化过程中能够产生大量的可变亚型来应对微生物病原体对机体的入侵与感染. 近些年来,越来越多的研究表明硬骨鱼中的皮肤黏膜不仅起到物理屏障的作用,而且其特异的免疫应答对机体防御病原至关重要,尤其是可溶性蛋白质及受体等分子免疫功能的发现为进一步探明免疫分子与病原体结合、炎症的中和、调理或分子和受体的互作提供了理论依据. 黏膜屏障是一种动态结构,它允许鱼类在保持体内平衡的同时与外部环境相互作用. 本文分析了皮肤黏膜免疫系统在硬骨鱼类整体健康中的重要性,通过概述硬骨鱼的皮肤结构特征,以及黏膜免疫系统中的免疫细胞和分子的作用模式,阐明皮肤中黏膜免疫系统的防御机制,同时,本文还总结了硬骨鱼类的皮肤黏膜系统中微生物种群的稳态以及与环境之间的互作机制. 虽然当前对全面了解硬骨鱼类皮肤黏膜免疫系统的相关研究仍然较少,但本篇综述将有助于研究人员更进一步地了解当前皮肤黏膜免疫的相关研究进展,为推动该领域的研究、揭示硬骨鱼类皮肤黏膜免疫的调控机制提供一定的理论支持,为将来的鱼类疾病防控提供科学依据,同时也为鱼类养殖行业提供新的免疫调控策略和方法.
Abstract:
The immune system of teleost fish is very similar to that of other vertebrates, primarily functioning through the involvement of soluble proteins, receptors, and immune cells. These soluble proteins have evolved to produce a large number of variable isoforms in response to the invasion and infection of microbial pathogens in fish. In recent years, increasing evidence has shown that the skin mucosa of teleost fish is not only a physical barrier but also plays a crucial role in the defense against pathogens, especially with the discovery of soluble proteins and receptors, which provide a theoretical basis for further understanding the interaction between immune molecules and pathogens, neutralization of inflammation, regulation, or the interaction between molecules and receptors. The mucosal barrier is a dynamic structure that allows fish to interact with the external environment while maintaining homeostasis. This article analyzes the importance of the skin mucosal immune system in the overall health of teleost fish, by outlining the structural characteristics of the skin in teleost fish, and the patterns of action of immune cells and molecules in the mucosal immune system, it clarifies the defense mechanisms of the mucosal immune system in the skin. Additionally, the article summarizes the homeostasis of microbial populations in the skin mucosal system of teleost fish and the interaction mechanisms with the environment. Although current research on the comprehensive understanding of the skin mucosal immune system in teleost fish is still limited, this review will help researchers to further understand the current progress in skin mucosal immunity research, provide some theoretical support for promoting research in this field, reveal the regulatory mechanisms of skin mucosal immunity in teleost fish, provide a scientific basis for future fish disease prevention and control, and also provide new immune regulation strategies and methods for the fish farming industry.

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备注/Memo

备注/Memo:
收稿日期:2025-02-22.
基金项目:辽宁省应用基础研究计划项目(2022JH2/101300139)、辽宁省教育厅基础研究项目(JL202003).
通讯作者:王伟,博士,教授,研究方向:鱼类应用生物学、鱼类繁育及新品种创制与开发. E-mail:wangwei@dlou.edu.cn; 李雪洁,博士,讲师,研究方向:海水鱼类胚胎发育生物学及黏膜免疫学. E-mail:lixuejie@dlou.edu.cn
更新日期/Last Update: 2025-10-20