[1]冯君茜,孙昌俊.相转移法合成哒嗪类糖苷[J].南京师大学报(自然科学版),2008,31(04):89-91.
 Feng Junqian,Sun Changjun.Several Pyridazine Glycosides Synthesized Under Phase Transfer Catalysis[J].Journal of Nanjing Normal University(Natural Science Edition),2008,31(04):89-91.
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相转移法合成哒嗪类糖苷()
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《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

卷:
第31卷
期数:
2008年04期
页码:
89-91
栏目:
化学
出版日期:
2008-12-30

文章信息/Info

Title:
Several Pyridazine Glycosides Synthesized Under Phase Transfer Catalysis
作者:
冯君茜1 孙昌俊2
( 1. 山东警察学院刑事科学技术系, 山东济南250014 )
( 2. 山东大学化学与化工学院, 山东济南250100)
Author(s):
Feng Junqian1Sun Changjun2
1.Department of Criminal Science and Technology,Shandong Police Institute,Jinan 250014,China
关键词:
哒嗪酮 糖苷 相转移催化法 抗癌化合物
Keywords:
py ridazine g lyc is ide PTC antitum or com pound
分类号:
TQ463.53
摘要:
本文采用相转移法,使乙酰基-α-D-溴代糖1(A-C)与6-(4-甲氧基)苯基-3(2H)-哒嗪酮2以及6-(4-羟基苯基)-4,5-二氢-3(2H)-哒嗪酮5反应合成了3(A,C)及6(A,B)四个乙酰基糖苷化合物.其中3A经氨解脱去保护基又得到一个化合物4A′.其结构被IR、1 HNMR和元素分析所证实.
Abstract:
Tw o N-g lycosides 3( A、C) o f 6-( 4-m ethoxyphenyl) -3( 2H ) -pyr idazinone 2 and tw o O-g lycosides 6( A、B) o f 6-( 4-hydroxyphenyl) -4, 5-d ihydro-3 ( 2H ) -pyr idazinone 5 were synthesized under phase transfe r cata ly sis. Compound 3A was treated by amm onia to g ive compound 4A’ . The ir structu res w ere con firm ed by elem entary analysis, IR, and 1HNMR.

参考文献/References:

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[ 8] 陈再成, 孙昌俊, 胡为峰. 2, 6-二甲基-3, 5-二氯-4-吡啶酚糖苷的合成[ J]. 有机化学, 1992: 269-272.

备注/Memo

备注/Memo:
通讯联系人: 冯君茜, 博士生, 副教授, 研究方向: 有机合成. E-m ail: junq ianfeng@ 163. com
更新日期/Last Update: 2013-05-05