[1]陈建忠,郭各朴,张永昊,等.固态发泡组织工程支架材料的热重法特性分析[J].南京师大学报(自然科学版),2010,33(04):48-52.
　Chen Jianzhong,Guo Gepu,Zhang Yonghao,et al.Thermal Gravitmeric Analysis for Solid-State Foamed Tissue Engineering Scaffold[J].Journal of Nanjing Normal University(Natural Science Edition),2010,33(04):48-52.
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固态发泡组织工程支架材料的热重法特性分析()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第33卷
期数:
2010年04期
页码:
48-52
栏目:
物理学
出版日期:
2010-12-20

文章信息/Info

Title:
Thermal Gravitmeric Analysis for Solid-State Foamed Tissue Engineering Scaffold
作者:
陈建忠;郭各朴;张永昊;马青玉;
南京师范大学物理科学与技术学院, 江苏南京210046
Author(s):
Chen Jianzhong; Guo Gepu; Zhang Yonghao; Ma Qingyu
School of Physics and Technology,Nanjing Normal University,Nanjing 210046,China
关键词:
组织工程支架;  聚乳酸;  固态发泡法;  热重分析
Keywords:
tissue eng ineer ing sca ffo ld;  PLA;  solid??state foam ing;  TGA
分类号:
R318.08
摘要:
根据组织工程支架材料的特点和要求,设计了CO2固态发泡实验系统,对生物可降解聚合物聚乳酸(PLA)进行不同实验参数下的发泡制作,获得具有不同孔径大小的PLA支架泡沫材料;然后用热重分析法对PLA支架材料进行热稳定性的测量和对比,结果表明饱和压力越大,PLA支架泡孔密度越大,泡孔孔径越小,其分解温度就越低,37℃常温降解时间却越长.因此通过适当选取制作条件可以有效控制材料的特性来满足不同组织支架应用的需要.
Abstract:
Based on the character istic demands o f tissue eng ineer ing scaffo ld, a so lidstate foam ing system was designed to pe rfo rm them icroce llu lar foam fabr ica tion fo r the b iodeg radab le m ate rial PLA and severa l PLA foam s w ith different pore sizes fabr ica ted at various param eters. The therm ograv im etry was app lied to ana lyze the therma l stability and the on set tem pera ture of the fabricated PLA foam s, and the raw PLA m ater ia lwas a lso investiga ted for compar ison. It is proved tha t the bigg er po re size and h ighe r ce ll density of the PLA foam can be obta ined w ith low er onset temperature and longer deg radation tim e a t body tem perature o f 37℃ So the stable property can be e ffectively contro lled w ith appropriate fabri ca tion cond ition to adapt the requ irem ent fo r va rious app lications o f tissue eng ineering scaffo ld.

参考文献/References:

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[ 15]傅忠君, 郑化, 于鲁汕. 差热分析在聚乳酸纤维染色中的应用[ J]. 山东理工大学学报: 自然科学版, 2008, 22( 2): 31-36.

相似文献/References:

[1]冯晓健,等.聚乳酸头孢唑啉钠微球的制备及其释药性能[J].南京师大学报(自然科学版),2008,31(03):76.
　Feng Xiaojian,Wang Wei,Zhao Min.Preparation and Drug-releasing Performance Research of Polylactic Acid-cefazolin Sodium Microspheres[J].Journal of Nanjing Normal University(Natural Science Edition),2008,31(04):76.

备注/Memo

备注/Memo:
基金项目: 国家自然科学基金( 10974098)、江苏省科技厅自然科学基金( BK2009407 )、教育部博士点基金( 20093207120003) . 通讯联系人: 马青玉, 博士, 副教授, 研究方向: 生物医学工程和生物医学电子技术. Email:maqingyu@ njnu. edu. cn
更新日期/Last Update: 2013-04-08