[1]王 昉,盛沈俊,赵定勇,等.米力农的热稳定性研究[J].南京师大学报(自然科学版),2013,36(03):53-56.
　Wang Fang,Sheng Shenjun,Zhao Dingyong,et al.Study of the Thermal Stability of Milrinone[J].Journal of Nanjing Normal University(Natural Science Edition),2013,36(03):53-56.
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米力农的热稳定性研究()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第36卷
期数:
2013年03期
页码:
53-56
栏目:
化学
出版日期:
2013-09-30

文章信息/Info

Title:
Study of the Thermal Stability of Milrinone
作者:
王 昉1; 盛沈俊1; 2; 赵定勇2; 王晓姝3; 陈华明4
(1.南京师范大学分析测试中心,江苏 南京 210023) (2.南京师范大学化学与材料科学学院,江苏 南京 210023) (3.苏州大学司法鉴定所,江苏 苏州 215000) (4.南京康然医药科技有限公司,江苏 南京 210028)
Author(s):
Wang Fang1; Sheng Shenjun1; 2; Zhao Dingyong2; Wang Xiaoshu3; Chen Huaming4
(1.Analysis and Testing Center,Nanjing Normal University,Nanjing 210023,China) (2.School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China) (3.Institute of Forensic Sciences,Soochow University,Suzhou 215000,China) (4.Chemzam Phamtech Co.Ltd,Nanjing 210028,China)
关键词:
米力农; 热重分析; 热稳定性; 动力学
Keywords:
Milrinone; TGA; stability; kinetics
分类号:
O642.3
摘要:
利用热重分析技术研究了米力农药物在氮气气氛下的热分解动力学,采用Flynn-Wall-Ozawa法和Kissinger法,计算了该药物的热分解反应活化能E和指前因子lnA,并进行了比较.结果表明,Flynn-Wall-Ozawa法和Kissinger法计算所得活化能比较接近,米力农药物的平均活化能为165.69 kJ/mol,指前因子lnA为32.44 s-1,热解反应级数为n=1.00.并推断了米力农药物在室温298.15 K下的存放有效期为4年.热重分析法可以便捷、科学、经济地预测药物的稳定性和贮存期,为该药物的生产与评价提供参考依据.
Abstract:
Thermogravimetric analysis(TGA)was used to study the thermal decomposition kinetics of Milrinone in the nitrogen atmosphere.The thermal decomposition kinetic parameters of activation energies(E)and pre-exponential factors(lnA)of Milrinone were calculated by the Flynn-Wall-Ozawa method and Kissinger method.The results showed that the activation energy Ea of the drug that calculated by the two methods were similar.The average activation energy Ea was 165.69 kJ/mol,pre-exponential factors lnA was 32.44 s-1,the reaction order of the thermal decomposition of Milrinone was 1.00.The store period of this drug was four years under 298.15 K.The thermalgravimetric analysis is a rapid,convenient and feasible method for discussing the stability and the store period of the drug,and the results of this experiment provide a reference for production and appraisal of Milrinone drug.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2013-04-01.
基金项目:江苏省高校自然科学基金(09KJD350001)、江苏省生物医药测试服务平台(BM2007132)资助.
通讯联系人:王昉,高级实验师,研究方向:仪器分析.E-mail:wangfang@njnu.edu.cn
更新日期/Last Update: 2013-09-30