[1]许艳华,刘 津,陈华群.雷公藤红素抑制C2C12细胞增殖及诱导其凋亡[J].南京师大学报(自然科学版),2013,36(03):93-96.
　Xu Yanhua,Liu Jin,Chen Huaqun.Inhibition Effects of the Proliferation and Induction of the Apoptosis Of Celastrol In C2C12 Cells[J].Journal of Nanjing Normal University(Natural Science Edition),2013,36(03):93-96.
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雷公藤红素抑制C2C12细胞增殖及诱导其凋亡()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第36卷
期数:
2013年03期
页码:
93-96
栏目:
生命科学
出版日期:
2013-09-30

文章信息/Info

Title:
Inhibition Effects of the Proliferation and Induction of the Apoptosis Of Celastrol In C2C12 Cells
作者:
许艳华; 刘 津; 陈华群
南京师范大学生命科学学院,江苏省分子医学生物技术重点实验室,江苏 南京 210023
Author(s):
Xu Yanhua; Liu Jin; Chen Huaqun
Jiangsu Key Laboratory for Molecular and Medical Biotechnology,School of Life Sciences, Nanjing Normal University,Nanjing 210023,China
关键词:
雷公藤红素; C2C12成肌细胞; 细胞增殖; 细胞凋亡
Keywords:
Celastrol; C2C12 myoblast; cell proliferation; cell apoptosis
分类号:
Q28
摘要:
雷公藤红素(Celastrol)是传统草药雷公藤根部有效的提取成分,被广泛用于炎症性疾病如类风湿性关节炎、肾炎等治疗.近年来发现,其能抑制肿瘤细胞增殖,具有诱人的肿瘤治疗应用前景.本研究观察到雷公藤红素会抑制C2C12小鼠骨骼肌母细胞的增殖,并可能通过诱导Caspase-3的降解致使C2C12凋亡,提示雷公藤红素临床应用的安全性值得关注.
Abstract:
Celastrol is an effective content extracted from god vine,a traditional herb.It has been widely used in the treatment of arthritics and nephritis.Recently,it has further been found to suppress the proliferation of tumor cells,and as a potential candidate to treat tumor.We report in this study that in vitro,Celastrol inhibits the proliferation of mouse myoblast,C2C12 cells,as well as induces apoptosis through activation of Caspase-3.Our datas suggest that the safety of Celastrol is needed to be further investigated.

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备注/Memo

备注/Memo:
收稿日期:2013-03-13.
基金项目:江苏省优势学科资助项目(PAPD).
通讯联系人:陈华群,博士,教授,研究方向:骨骼肌和内皮细胞生物学.E-mail:Chenhuaqun@njnu.edu.cn
更新日期/Last Update: 2013-09-30