[1]邹 阳,王 伟,温传俊.低氧通过HIF-2α诱导CCNE2 表达的初步研究[J].南京师大学报(自然科学版),2014,37(02):96.
　Zou Yang,Wang Wei,Wen Chuanjun.Study on Hypoxia Induced the Expression of CCNE2 by HIF-2α[J].Journal of Nanjing Normal University(Natural Science Edition),2014,37(02):96.
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低氧通过HIF-2α诱导CCNE2 表达的初步研究()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第37卷
期数:
2014年02期
页码:
96
栏目:
生命科学
出版日期:
2014-06-30

文章信息/Info

Title:
Study on Hypoxia Induced the Expression of CCNE2 by HIF-2α
作者:
邹 阳; 王 伟; 温传俊
南京师范大学生命科学学院,江苏省分子医学生物技术重点实验室,江苏南京210023
Author(s):
Zou Yang; Wang Wei; Wen Chuanjun
School of Life Sciences,Nanjing Normal University,Jiangsu Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210023,China
关键词:
低氧; MCF-7; HIF-2α; CCNE2
Keywords:
hypoxia; MCF-7; HIF-2α; CCNE2
分类号:
Q291
文献标志码:
A
摘要:
低氧是肿瘤发生侵袭转移必经的过程之一,它促进了肿瘤致癌基因的表达,从而使肿瘤细胞发生远处转移. 低氧环境对于调节肿瘤的EMT 过程具有重要作用,刺激肿瘤的恶化和转移,也可促进血管激活因子的表达从而促进肿瘤血管的形成. CCNE2 作为调节细胞周期的关键基因,在肿瘤发生和转移过程中的作用已经得到广泛研究,在多种癌细胞中都发现CCNE2 蛋白是高表达的. 为此在MCF-7 细胞中通过一系列的实验证明了CCNE2 是一个新的低氧靶基因,并证明了低氧通过刺激HIF-2α促进了CCNE2 的表达.
Abstract:
Hypoxia is one of the process of tumorigenesis and tumor metastasis,it promotes the expression of tumors which promotes tumor cells distant metastasis. Hypoxia plays an important role in EMT process, which stimulates the degradation and metastasis of tumor,moreover,it promotes the expression of vascular activator to induce the formation of tumor blood vessels. As a key regulating in cell cycle genes,the role of CCNE2 in tumorigenesis and metastasis has been extensively studied,CCNE2 is found to express more than normal cells in various cancer cells. For these,a series of ex- periments are done to demonstrate CCNE2 is a new target to hypoxia and hypoxia induces the expression of CCNE2 by HIF-2α.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2014-02-24.
基金项目:国家自然科学基金(2012104GZ30057).
通讯联系人:温传俊,副教授,研究方向:肿瘤分子细胞生物学. E-mail:wenchuanjun@hotmail.com
更新日期/Last Update: 2014-06-30