[1]杨文娟,丁贺,刘新华,等.Nrf2调控SIRT6表达的初步研究[J].南京师范大学学报(自然科学版),2015,38(03):49.
 YangWenjuan,DingHe,LiuXinhua,et al.ThePreliminaryStudyonNrf2RegulatingSIRT6Expression[J].Journal of Nanjing Normal University(Natural Science Edition),2015,38(03):49.
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Nrf2调控SIRT6表达的初步研究()
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《南京师范大学学报》(自然科学版)[ISSN:1001-4616/CN:32-1239/N]

卷:
第38卷
期数:
2015年03期
页码:
49
栏目:
生命科学
出版日期:
2015-09-30

文章信息/Info

Title:
ThePreliminaryStudyonNrf2RegulatingSIRT6Expression
作者:
杨文娟丁贺刘新华刘海霞桑泽玲温传俊
南京师范大学生命科学学院,江苏省分子细胞生物学研究所,江苏南京210023
Author(s):
YangWenjuanDingHeLiuXinhuaLiuHaixiaSangZelingWenChuanjun
SchoolofLifeSciences,NanjingNormalUniversity,JiangsuProvinceKeyLaboratoryforMolecularandMedicalBiotechnology,Nanjing210023,China
关键词:
衰老Nrf2SIRT6
Keywords:
agingNrf2SIRT6
分类号:
Q28
文献标志码:
A
摘要:
衰老是一个普遍的、动态的,并持续发展的复杂过程.对其机制的研究中,比较公认的是氧化应激损伤理论,其中核转录因子Nrf2发挥重要的作用,这一理论主要强调在寿命调节中Nrf2的抗氧化作用.而本实验结合生物信息学、生物化学、细胞生物学等方法证明去乙酰化酶蛋白家族成员SIRT6的表达受Nrf2的调控,即提示Nrf2的抗衰老作用可能是通过SIRT6发挥作用.
Abstract:
Agingisanuniversal,dynamic,complexprocess.Theoxidativestresstheoryisagenerallyrecognizedexplanationofamolecularmechanismunderlyingtheagingprocess.ThenucleartranscriptionfactorNrf2playsanimportantroleinthisprocess.AseriesofexperimentsweredonetoverifythatSIRT6wasapossibletargetgeneofNrf2anditmayactinconjunctionwithNrf2.

参考文献/References:

[1]HarmanD.Freeradicaltheoryofaging:anupdate:increasingthefunctionallifespan[J].AnnNYAcadSci,2006,1067:10-21.
[2]ZhangDD,LoSC,CrossJV,etal.Keap1isaredox-regulatedsubstrateadaptorproteinforaCul3-dependentubiquitinligasecomplex[J].MolCellBiol,2004,24:10941-10953.
[3]KobayashiM,YamamotoM.MolecularmechanismsactivatingtheNrf2-Keap1pathwayofantioxidantgeneregulation.Antioxid[J].RedoxSignal,2005,7:385.
[4]KanfiY,DavidB,LombardA,etal.Sortingoutsirtuins[J].Nature,2012,483:218-221.(下转第63页)
[5]ItohK,MochizukiM,IshiiY,etal.TranscriptionfactorNrf2regulatesinflammationbymediatingtheeffectof15-deoxy-D12,14-prostaglandinJ2[J].CellBiol,2004,24:36-45.
[6]AndersenPK,BorganO,GillRD,etal.StatisticalModelsBasedonCountingProcesses[M].NewYork:Springer,1993:1?797-1798.
[7]KanfiY,NaimanS,AmirG,etal.ThesirtuinSIRT6regulateslifespaninmalemice[J].Nature,2012,483(7388):218-221.
[8]SykiotisG,BohmannD.Keap1/Nrf2signalingregulatesoxidativestresstoleranceandlifespanindrosophila[J].DevelopmentalCell,2008,14(1):76-85.
[9]MotohashiH,YamamotoM.Nrf2-Keap1definesaphysiologicallyimportantstressresponsemechanism[J].TrendsMolMed,2004,10:549-557.
[10]LeeJM,LiJ,JohnsonDA,etal.Nrf2,amulti-organprotector?[J].FASEBJ,2005,19:1061-1066.
[11]HarperJM,SalmonAB,ChangY,etal.Stressresistanceandaging:influenceofgenesandnutrition[J].MechAgeingDev,2006,127:687-694.
[12]MurakamiS.Stressresistanceinlong-livedmousemodels[J].ExpGerontol,2006,41:1014-1019.
[13]Pe′rezVI,VanRemmenH,BokovA,etal.Theover-expressionofmajorantioxidantenzymesdoesnotextendthelifespanofmice[J].AgingCell,2009(8):73-75.
[14]McCordRA,MichishitaE,HongT,etal.SIRT6stabilizesDNA-dependentproteinkinaseatchromatinforDNAdouble-strandbreaking[J].Aging,2009(1):109-121.

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备注/Memo

备注/Memo:
收稿日期:2014-12-14.
基金项目:国家自然科学基金(2012104GZ30057).
通讯联系人:温传俊,副教授,研究方向:肿瘤分子细胞生物学.E-mail:wenchuanjun@hotmail.Com
更新日期/Last Update: 2015-09-30