[1]周婷,高婷婷,孙洪芳,等.结构特异性核酸内切酶FEN1及其与肿瘤的关系[J].南京师大学报(自然科学版),2014,37(02):7.
　Zhou Ting,Gao Tingting,Sun Hongfang,et al.FEN1’s Functional Regulation and Its Link to Cancer[J].Journal of Nanjing Normal University(Natural Science Edition),2014,37(02):7.
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结构特异性核酸内切酶FEN1及其与肿瘤的关系()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第37卷
期数:
2014年02期
页码:
7
栏目:
出版日期:
2014-06-30

文章信息/Info

Title:
FEN1’s Functional Regulation and Its Link to Cancer
作者:
周婷; 高婷婷; 孙洪芳; 潘飞燕; 何凌峰; 郭志刚
南京师范大学生命科学学院,江苏省分子医学生物技术重点实验室,江苏 南京 210023
Author(s):
Zhou Ting; Gao Tingting; Sun Hongfang; Pan Feiyan; He Linfeng; Guo Zhigang
School of Life Sciences,Nanjing Normal University,Jiangsu Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210023,China
关键词:
FEN1; DNA损伤修复; 肿瘤
Keywords:
FEN1; DNA repair; tumor
分类号:
Q2;Q243
文献标志码:
A
摘要:
FEN1是一种结构特异性的多功能核酸酶,具有5′->3′flap核酸内切酶(FEN)、缺口核酸内切酶(GEN)和核酸外切酶(EXO)三大酶切活力.在细胞内,FEN1在多条DNA代谢途径中起着重要作用,包括冈崎片段成熟、长片段碱基切除修复和端粒维持等.鉴于FEN1的复杂功能,细胞内必定存在着一套精确调控机制,以确保FEN1在合适的时间与地点发挥作用.FEN1功能失调将导致基因组的稳定性和完整性下降,最终诱发包括肿瘤在内的多种染色体相关的疾病.本文主要针对FEN1的功能调控、功能失调与肿瘤的关系做一个综述.
Abstract:
Flap endonuclease1(FEN1)is a kind of structurespecific multifunctional nuclease which contains 5′->3′ flap endonuclease(FEN)activity,gap endonuclease(GEN)activity and exonuclease(EXO)activity.The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways,including Okazaki fragment maturation,longpatch base excision repair and telomere maintenance.As such,FEN1 must be precisely regulated to execute each of its functions with the right timing and in a specific subcellular location.FEN1 dysfunction will lead to genomic stability and integrity descend,and eventually induce a variety of chromosomal diseases including tumor.This review mainly targets FEN1’s functional regulation and its link to cancer.

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备注/Memo

备注/Memo:
收稿日期:2014-02-16.
基金项目:国家重点基础研究发展计划(973计划)项目(2013CB911600)、国家自然科学基金(31271449)、江苏省杰出青年基金(BK20130044)、江苏省科技厅面上项目(BK2011783)、江苏省科技厅重点项目(BK20130061).
通讯联系人:郭志刚,教授,研究方向:肿瘤发生的分子机制研究.E-mail:08278@njnu.edu.com
更新日期/Last Update: 2014-06-30