[1]刘雪梅,迟富丽,谈 华,等.新生儿血培养病原菌分布及耐药性分析[J].南京师范大学学报(自然科学版),2016,39(03):106.[doi:10.3969/j.issn.1001-4616.2016.03.018]
Liu Xuemei,Chi Fuli,Tan Hua,et al.Analysis of the Pathogens Isolated from Blood Specimens ofNeonates and Their Antibiotic Resistance[J].Journal of Nanjing Normal University(Natural Science Edition),2016,39(03):106.[doi:10.3969/j.issn.1001-4616.2016.03.018]
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新生儿血培养病原菌分布及耐药性分析(
)
《南京师范大学学报》(自然科学版)[ISSN:1001-4616/CN:32-1239/N]
- 卷:
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第39卷
- 期数:
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2016年03期
- 页码:
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106
- 栏目:
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·生命科学·
- 出版日期:
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2016-09-30
文章信息/Info
- Title:
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Analysis of the Pathogens Isolated from Blood Specimens ofNeonates and Their Antibiotic Resistance
- 文章编号:
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1001-4616(2016)03-0106-04
- 作者:
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刘雪梅; 迟富丽; 谈 华; 朱纯亮; 韩 勍; 徐 飞
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南京医科大学附属儿童医院检验科,江苏 南京 210008
- Author(s):
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Liu Xuemei; Chi Fuli; Tan Hua; Zhu Chunliang; Han Qing; Xu Fei
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Department of Clinical Laboratory,Children’s Hospital of Nanjing Medical University,Nanjing 210008,China
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- 关键词:
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血培养; 新生儿; 病原菌; 耐药性
- Keywords:
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neonate; pathogen; blood culture; antibiotic resistance
- 分类号:
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R446.5
- DOI:
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10.3969/j.issn.1001-4616.2016.03.018
- 文献标志码:
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A
- 摘要:
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为了解本院新生儿病房血培养病原菌的分布及主要病原菌对抗菌药物的耐药性,本研究分析了2015年1月至2015年12月新生儿病房送检的血培养标本所分离病原菌的种类及抗菌药物耐药情况. 结果共分离到病原菌236株,其中革兰阳性菌192株(81.36%),以凝固酶阴性葡萄球菌为主;革兰阴性杆菌40株(16.95%),以大肠埃希菌为主. 药敏结果显示,凝固酶阴性葡萄球菌耐药率较高,其中耐甲氧西林检出率占82.69%,未检出耐奎奴普丁/达福普汀、替加环素、利奈唑烷和万古霉素的葡萄球菌;主要革兰阴性菌对氨苄西林、复方新诺明、庆大霉素耐药率较高,未检出耐阿米卡星、头孢吡肟、头孢他啶、头孢替坦、妥布霉素、亚胺培南菌株. 结论:本院新生儿血培养病原菌以革兰阳性菌为主,凝固酶阴性葡萄球菌是主要病原菌,并且耐药率较高.
- Abstract:
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To investigate the distribution and antibiotic resistance of pathogens isolated from blood specimens of neonates,the clinical data of neonatal blood cultures were statistically analyzed from January 2015 to December 2015. A total of 236 pathogenic strains were isolated,including gram-positive bacteria(81.36%),Coagulase-negative Staphylococcus were predominant;40 strains of gram-negative bacteria Escherichia coli were predominant. The drug resistances of Coagulase-negative Staphylococcus were high,MRCNS were 82.69%,no Quinupristin/Dalfopristin,Tigecycline,Vancomycin and Linezolid resistant strains were found. The resistances of main Gram-negative pathogens to Ampicillin,SMZ-TMP,Levofloxacin,Gentamicin were high. No Amikacin,cefepime,ceftazidime,cefotetan,tobramycin,imipenem resistant strains were found. The refults showed that Gram-positive bacteria were the main pathogens in the hosptial,among which Coagulase-negative Staphylococcus was the predominant pathogen with high drug resistance.
参考文献/References:
[1] 邵肖梅. 抗生素治疗新生儿感染的问题及对策[J]. 中华儿科杂志,2003,41(12):900-902.
[2] 孙长贵,译. M100-S23 抗菌药物敏感性试验执行标准第二十五版资料增刊[S]. USA:CLSI,2015.
[3] 陈子松,李磊,周杭杰,等. 新生儿血培养阳性病原菌分布及耐药状况分析[J]. 中国微生态学杂志,2015,27(6):715-717.
[4] 旷凌寒,江永梅,胡正强,等. 新生儿科血培养病原菌变迁及主要病原菌耐药性分析[J]. 现代预防医学,2013,40(5):837-839.
[5] 吉彤珍,钟京梅,刘晶. 475例NICU新生儿血培养阳性菌分布及耐药性分析[J]. 中国卫生检验杂志,2014,24(15):2 267-2 268.
[6] 林青挺,林雪峰,周文斐. 新生儿血培养耐甲氧西林凝固酶阴性葡萄球菌的鉴定及耐药性分析[J]. 中国误诊学杂志,2007,7(20):4 763-4 764.
备注/Memo
- 备注/Memo:
-
收稿日期:2016-03-02.
通讯联系人:徐飞,副主任技师,研究方向:临床微生物检验. E-mail:feixu1975@126.com
更新日期/Last Update:
2016-09-30