[1]陈梦玲,朱 胜,朱 熙,等.味觉敏感性与结肠疾病的相关性研究[J].南京师范大学学报(自然科学版),2017,40(01):99.[doi:10.3969/j.issn.1001-4616.2017.01.015]
 Chen Mengling,Zhu Sheng,Zhu Xi,et al.Association between Taste Sensitivity and Conlonic Diseases[J].Journal of Nanjing Normal University(Natural Science Edition),2017,40(01):99.[doi:10.3969/j.issn.1001-4616.2017.01.015]
点击复制

味觉敏感性与结肠疾病的相关性研究()
分享到:

《南京师范大学学报》(自然科学版)[ISSN:1001-4616/CN:32-1239/N]

卷:
第40卷
期数:
2017年01期
页码:
99
栏目:
·地理学·
出版日期:
2017-03-31

文章信息/Info

Title:
Association between Taste Sensitivity and Conlonic Diseases
文章编号:
1001-4616(2017)01-0099-05
作者:
陈梦玲1朱 胜2朱 熙1朱文杰1鞠钰蕊1周心怡1张根华1
(1.常熟理工学院生物与食品工程学院,江苏 常熟 215500)(2.常熟市第五人民医院,江苏 常熟 215500)
Author(s):
Chen Mengling1Zhu Sheng2Zhu Xi1Zhu Wenjie1Ju Yurui1Zhou Xinyi1Zhang Genhua1
(1.College of Biology and Food Engineering,Changshu Institute of Technology,Changshu 215500,China)(2.Changshu Fifth People’s Hospital,Changshu 215500,China)
关键词:
味觉丙硫氧嘧啶结肠息肉炎症
Keywords:
taste6-n-Propylthiouracil(PROP)colonpolypsinflammation
分类号:
Q189
DOI:
10.3969/j.issn.1001-4616.2017.01.015
文献标志码:
A
摘要:
以常熟市各大医院肠镜检查者中的志愿者为受试对象,通过蘸涂法检测其甜味、苦味阈值,结合肠镜检查报告和饮食问卷调查,探讨味觉敏感性与结肠疾病的关系. 结果显示,甜味、苦味敏感性均随年龄增长而下降. 对所有受试对象进行分析,结肠炎症组与息肉组的苦味阈值较正常组显著增高,而甜味阈值无显著差异; 但是炎症组和息肉组的年龄显著大于正常组. 进一步分析45~64岁年龄段(组间无年龄差异),结肠炎或息肉患者的甜味阈值显著低于正常组,而苦味阈值没有变化. 该研究提示,甜味敏感性高的人群,膳食纤维摄入较少,罹患结肠疾病的风险较高. 此外,甜味阈值测试对及早诊治结肠炎或结肠息肉、预防结肠癌的发生以及保护人类健康具有重要价值.
Abstract:
People ready to undergo colonoscopy were recruited volenteer as subjects from several major hospitals in Changshu city. Dip-coating method was used to detect the sweet and bitter taste thresholds. The relationship between taste sensitivity and colonic diseases was discussed based on the taste tests,colonoscopy reporting and diet questionnaire. The results showed that sweet,bitter sensitivity were decreased with age. When all subjects were analyzed,the bitterness threshold of colitis and polyp groups was significantly higher than normal group,but the sweetness threshold had no significance; however,the age of colitis and polyp groups was significantly greater than the normal group. Further analysis on the age of 45~64 years(no age difference among the three groups)showed that,sweetness threshold in colitis or polyps group was significantly lower than the normal group,while the bitterness threshold did not change. It suggests that people with high sweet sensitivity,less dietary fiber intake,have higher the risk of colon disease. In addition,the sweetness threshold test has great value for the early diagnosis and treatment of colitis or colon polyps,colon cancer prevention and the protection of human health.

参考文献/References:

[1] BASSON M D,BARTOSHUK L M,DICHELLO S Z,et al. Association between 6-n-propylthiouracil(PROP)bitterness and colonic neoplasms[J]. Dig Dis Sci,2005,50(3):483-489.
[2]TEPPER B J,WHITE E A,KOELLIKER Y,et al. Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection[J]. Ann N Y Acad Sci,2009(1 170):126-139.
[3]YANG W G,CHEN C B,WANG Z X,et al. A case-control study on the relationship between salt intake and salty taste and risk of gastric cancer[J]. World J Gastroenterol,2011,17(15):2 049-2 053.
[4]ZHONG C,LI K N,BI J W,et al. Sodium intake,salt taste and gastric cancer risk according to Helicobacter pylori infection,smoking,histological type and tumor site in China[J]. Asian Pac J Cancer Prev,2012,13(6):2 481-2 484.
[5]ZHANG Z,ZHANG X. Salt taste preference,sodium intake and gastric cancer in China[J]. Asian Pac J Cancer Prev,2011,12(5):1 207-1 210.
[6]张根华. 甜味偏好可塑性的味觉细胞学基础[D]. 杭州:浙江工商大学,2007.
[7]陈德国,武华. 复合膳食纤维对溃疡性结肠炎患者肠黏膜屏障功能的影响[J]. 中国医药导报,2013,10(4):34-38.
[8]王少鑫,高歌. 饮食对溃疡性结肠炎的致病及治疗作用[J]. 国外医学:消化系疾病分册,2003,23(1):21-23.
[9]BEAUCHAMP G K,MENNELLA J A. Early flavor learning and its impact on later feeding behavior[J]. J Pediatr Gastroenterol Nutr,2009,48(Suppl 1):S25-30.
[10]BEAUCHAMP G K,MENNELLA J A. Flavor perception in human infants:development and functional significance[J]. Digestion,2011,83(Suppl 1):1-6.
[11]MENNELLA J A,FORESTELL C A,MORGAN L K,et al. Early milk feeding influences taste acceptance and liking during infancy[J]. Am J Clin Nutr,2009,90(Suppl 1):780S-788S.
[12]CHEN M L,LIU S S,ZHANG G H,et al. Effects of early intraoral acesulfame-K stimulation to mice on the adult’s sweet preference and the expression of α-gustducin in fungiform papilla[J]. Chem Senses,2013,38(5):447-455.
[13]LI W L,CHEN M L,LIU S S,et al. Sweet preference modified by early experience in mice and the related molecular modulations on the peripheral pathway[J]. J Mol Neurosci,2013,51(1):225-236.
[14]ZHANG G H,CHEN M L,LIU S S,et al. Effects of mother’s dietary exposure to acesulfame-K in pregnancy or lactation on the adult offspring’s sweet preference[J]. Chem Senses,2011,36(9):763-770.
[15]ZHANG G H,CHEN M L,LIU S S,et al. Facilitation of the development of fungiform taste buds by early intraoral acesulfame-K stimulation to mice[J]. J Neural Transm,2010,117(11):1 261-1 264.
[16]刘斯斯,李伟丽,李国梁,等. 早期咖啡因暴露对成年小鼠苦味适应的影响[J]. 南京师大学报(自然科学版),2013,36(1):79-84.
[17]李伟丽,陈梦玲,李国梁,等. 生后发育早期甜味经历影响老年甜味偏好[J]. 南京师大学报(自然科学版),2013,36(4):100-106.

备注/Memo

备注/Memo:
收稿日期:2015-10-25.
基金项目:国家自然科学基金(NSFC31200812)、国家级大学生创新创业训练计划项目((201310333001)、江苏省第五期“333工程”第三层次培养对象(2016)、常熟市医药科技计划项目(csws201411).
通讯联系人:张根华,教授,博士,研究方向:食品感官评价. E-mail:zgh@cslg.cn
更新日期/Last Update: 1900-01-01