[1]杨 晨,耿月攀,田 然.哺乳动物谷胱甘肽转移酶研究进展[J].南京师大学报(自然科学版),2021,(01):91-98.[doi:10.3969/j.issn.1001-4616.2021.01.013]
 Yang Chen,Geng Yuepan,Tian Ran.Advance in Mammalian Glutathione Transferase Research[J].Journal of Nanjing Normal University(Natural Science Edition),2021,(01):91-98.[doi:10.3969/j.issn.1001-4616.2021.01.013]
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哺乳动物谷胱甘肽转移酶研究进展()
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《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

卷:
期数:
2021年01期
页码:
91-98
栏目:
·生物学·
出版日期:
2021-03-15

文章信息/Info

Title:
Advance in Mammalian Glutathione Transferase Research
文章编号:
1001-4616(2021)01-0091-08
作者:
杨 晨耿月攀田 然
南京师范大学生命科学学院,江苏 南京 210023
Author(s):
Yang ChenGeng YuepanTian Ran
School of Life Sciences,Nanjing Normal University,Nanjing 210023,China
关键词:
谷胱甘肽转移酶抗氧化解毒
Keywords:
glutathione transferasesanti-oxidationdetoxification
分类号:
Q71
DOI:
10.3969/j.issn.1001-4616.2021.01.013
文献标志码:
A
摘要:
谷胱甘肽转移酶(谷胱甘肽硫转移酶)(GSTs)是一类广泛分布于微生物、植物、昆虫、鱼以及哺乳动物,在诸多生物学过程中发挥重要作用的蛋白超家族,具有解毒和清除过氧化物双重功能. 近年来,国内外研究人员进一步对GST在生物化学、结构生物学、分子生物学、进化生物学以及基因组学等层面进行了大量的分析和研究. 本文将针对有关GST的研究展开综述,以期为深入开展哺乳动物GST基因适应和进化研究提供借鉴.
Abstract:
Glutathione transferases(Glutathione S-transferases)(GSTs)are a classic proteins superfamily,which are widely distributed in microorganisms,plants,insects,fish and mammals. These enzymes play important roles in many biological processes,with dual functions of detoxification and scavenging peroxide. In recent years,researchers have conducted a lot of studies on GST in the areas of biochemistry,structural biology,molecular biology. Here,we review these GST researches in order to provide a reference for further investigation on adaptation and evolution of mammalian GST genes.

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备注/Memo

备注/Memo:
收稿日期:2020-03-16.
基金项目:国家自然科学基金青年科学基金项目(31900310)、中国博士后科学基金面上项目(2018M642278).
通讯作者:田然,博士,研究方向:进化基因组学. E-mail:tianrannjnu@163.com
更新日期/Last Update: 2021-03-15