[1]马雨璇,王 娜,王 冰,等.抗凝药利伐沙班晶型的定量分析与热稳定性考察[J].南京师大学报(自然科学版),2021,(01):136-140.[doi:10.3969/j.issn.1001-4616.2021.01.019]
 Ma Yuxuan,Wang Na,Wang Bing,et al.Quantitative Analysis and Thermal Stability of the CrystalForm of Rivaroxaban as an Anticoagulant[J].Journal of Nanjing Normal University(Natural Science Edition),2021,(01):136-140.[doi:10.3969/j.issn.1001-4616.2021.01.019]
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抗凝药利伐沙班晶型的定量分析与热稳定性考察()
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《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

卷:
期数:
2021年01期
页码:
136-140
栏目:
·药学·
出版日期:
2021-03-15

文章信息/Info

Title:
Quantitative Analysis and Thermal Stability of the CrystalForm of Rivaroxaban as an Anticoagulant
文章编号:
1001-4616(2021)01-0136-05
作者:
马雨璇王 娜王 冰李 钢
南京师范大学食品与制药工程学院,分析测试中心,江苏 南京 210023
Author(s):
Ma YuxuanWang NaWang BingLi Gang
School of Food and Pharmaceutical Engineering,Test & Analysis Center,Nanjing Normal University,Nanjing 210023,China
关键词:
利伐沙班定量分析定性分析热稳定性分析
Keywords:
Rivaroxabanquantitative analysisqualitative analysisthermal stability analysis
分类号:
R927
DOI:
10.3969/j.issn.1001-4616.2021.01.019
文献标志码:
A
摘要:
本文通过X-射线粉末衍射仪(PXRD)对利伐沙班混晶中的晶型Ⅰ和晶型Ⅱ进行了定性与定量分析,利用差示扫描量热仪(DSC)结合X 射线粉末衍射仪原位高温附件(in situ high temperature)测定了晶型Ⅱ的热稳定性. 定量分析采用X射线粉末衍射K值法,结果表明:该方法具有方便快速,简单实用的优点; 热分析表明晶型Ⅱ在190 ℃左右发生相转变,逐步转变为晶型Ⅰ.
Abstract:
In this paper,X-ray powder diffractometer(PXRD)was used to qualitatively and quantitatively analyze the crystal formⅠand crystal form Ⅱ in the mixed crystal of Riveraban. The thermal stability of crystal form Ⅱ was determined by differential scanning Calorimeter(DSC)combined with X-ray powder diffractometer in situ high temperature attachment. X-ray powder diffraction K value method is used for quantitative analysis,the results show that the method is convenient,rapid,simple and practical,and the thermal analysis shows that the phase transformation of crystal form Ⅱ occurs at about 190 ℃ and gradually changes to crystal form Ⅰ.

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备注/Memo

备注/Memo:
收稿日期:2019-12-25.
基金项目:江苏省大型科学仪器设备共享服务平台资助项目(BZ201403).
通讯作者:李钢,教授,研究方向:药物晶型,E-mail:40010@njnu.edu.cn
更新日期/Last Update: 2021-03-15