[1]黄 洋,曹睿杰,郭各朴,等.磁性纳米粒子的磁声谐波成像研究[J].南京师大学报(自然科学版),2022,45(02):1-8.[doi:10.3969/j.issn.1001-4616.2022.02.001]
　Huang Yang,Cao Ruijie,Guo Gepu,et al.Magnetoacoustic Harmonic Imaging Based on Magnetic Nanoparticles[J].Journal of Nanjing Normal University(Natural Science Edition),2022,45(02):1-8.[doi:10.3969/j.issn.1001-4616.2022.02.001]
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磁性纳米粒子的磁声谐波成像研究()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第45卷
期数:
2022年02期
页码:
1-8
栏目:
·物理学·
出版日期:
2022-05-15

文章信息/Info

Title:
Magnetoacoustic Harmonic Imaging Based on Magnetic Nanoparticles
文章编号:
1001-4616(2022)02-0001-08
作者:
黄 洋1; 曹睿杰1; 郭各朴1; 马青玉1; 郭余庆2; 1; 王 军2
(1.南京师范大学计算机与电子信息学院/人工智能学院,江苏 南京 210023)(2.江苏能建机电实业集团有限公司,江苏 泰州 225327)
Author(s):
Huang Yang1; Cao Ruijie1; Guo Gepu1; Ma Qingyu1; Guo Yuqing2; 1; Wang Jun2
(1.School of Computer and Electronic Information/School of Artificial Intelligence,Nanjing Normal University,Nanjing 210023,China)(2.Jiangsu Nengjian Electromechanical Industrial Co.,Ltd,Taizhou 225327,China)
关键词:
磁声谐波成像; 磁性纳米粒子; 锥形磁芯; 坡莫合金
Keywords:
magnetoacoustic harmonic imaging; magnetic nanoparticles(MNP); conical core; toroidal permalloy
分类号:
O441.3
DOI:
10.3969/j.issn.1001-4616.2022.02.001
文献标志码:
A
摘要:
磁性纳米粒子(MNPs)具有良好的磁响应、生物相容性和降解性等优点,在早期肿瘤诊疗中得到了广泛应用. 本文基于MNPs在交变磁场激励下的磁声谐波响应,利用锥形磁芯的汇聚作用,开展了基于MNPs的磁声谐波成像研究. 首先构建锥形磁芯的电磁激励模型,产生了具有大磁场强度/梯度分布的磁场区域,并基于MNPs的磁矩、机械振动和声传播研究了有效磁场区域内粒子的声辐射特性,推导了磁声谐波响应声压公式,实现了基于磁声谐波声压的二维扫描成像; 然后研究了非理想锥尖条件下平顶高度对有效磁场区域半径、声压以及穿透深度的影响,结果表明非理想锥尖可以提高磁声谐波响应和穿透深度,但会一定程度降低谐波成像分辨率; 最后利用环形坡莫合金的磁屏蔽效应来减小有效磁场区域,提高MNPs谐波成像的分辨率和对比度,在生物组织的浅表成像中展现良好的应用价值.
Abstract:
Due to the advantages of the good magnetic response,biocompatibility and biodegradability,magnetic nanoparticles(MNPs)have been widely used in early tumor diagnoses and treatments. In this paper,an imaging method based on the magnetoacoustic harmonic response of MNPs is studied by introducing the convergence effect of a conical iron cone. Firstly,the electromagnetic excitation model with a conical core is constructed to generate a focused effective magnetic field of high magnetic field intensity and its gradient. Based on the theories of the magnetic moment,mechanical vibration and acoustic radiation of MNPs,the magnetoacoustic harmonic pressure is analyzed and derived. Then,by considering the possible phenomena of a non-ideal cone tip,the influence of the flat top on the size of the effective magnetic volume,acoustic pressure and penetration depth is studied. The favorable results show that the non-ideal cone-tip model can be used to increase the pressure of the magnetoacoustic harmonic response with a deeper penetration,while leading to a decreased imaging accuracy to a certain extent. Finally,by introducing the magnetic shielding effect of a toroidal permalloy,the spatial resolution and the contrast of the magnetoacoustic harmonic imaging are further improved,exhibiting prosperous application potentials in the superficial imaging for biological tissues.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金重点项目(11934009)、国家自然科学基金面上项目(11974187,12174198)、南京师范大学课程思政教改项目(2021NSDJG028).
通讯作者:郭各朴,博士,副教授,研究方向:声信息处理、医学超声、电子技术. E-mail:guogepu@njnu.edu.cn
更新日期/Last Update: 1900-01-01