|Table of Contents|

Study of the Thermal Stability of Milrinone(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2013年03期
Page:
53-56
Research Field:
化学
Publishing date:

Info

Title:
Study of the Thermal Stability of Milrinone
Author(s):
Wang Fang1; Sheng Shenjun1; 2; Zhao Dingyong2; Wang Xiaoshu3; Chen Huaming4
(1.Analysis and Testing Center,Nanjing Normal University,Nanjing 210023,China) (2.School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China) (3.Institute of Forensic Sciences,Soochow University,Suzhou 215000,China) (4.Chemzam Phamtech Co.Ltd,Nanjing 210028,China)
Keywords:
Milrinone; TGA; stability; kinetics
PACS:
O642.3
DOI:
-
Abstract:
Thermogravimetric analysis(TGA)was used to study the thermal decomposition kinetics of Milrinone in the nitrogen atmosphere.The thermal decomposition kinetic parameters of activation energies(E)and pre-exponential factors(lnA)of Milrinone were calculated by the Flynn-Wall-Ozawa method and Kissinger method.The results showed that the activation energy Ea of the drug that calculated by the two methods were similar.The average activation energy Ea was 165.69 kJ/mol,pre-exponential factors lnA was 32.44 s-1,the reaction order of the thermal decomposition of Milrinone was 1.00.The store period of this drug was four years under 298.15 K.The thermalgravimetric analysis is a rapid,convenient and feasible method for discussing the stability and the store period of the drug,and the results of this experiment provide a reference for production and appraisal of Milrinone drug.

References:

[1] McMahon C J,Murchan H,Prendiville T,et al.Long-term support with Milrinone prior to cardiac transplantation in a neonate with left ventricular[J].Noncompaction Cardiomyopathy,2007,28(1):317-318.
[2]Tadasuke Use,Tetsuji Makita,Hiroyuki Ureshino,et al.Milrinone administered before ischemia or just after reperfusion,attenuates myocardial stunning in anesthetized swine[J].Basic Pharmacology,2006,20:327-334.
[3]陈双伟,杨建国,金庆平,等.米力农的合成工艺改进[J].中国药物化学杂志,2009,19(4):261-267.
[4]王新军,王慰.米力农的合成工艺研究[J].中国新技术新产品,2012(21):145-146.
[5]黄震华,朱雅琴.米利农和多巴酚丁胺治疗重度心力衰竭的疗效比较[J].中华现代医学与临床,2007,6(5):627-629.
[6]Ozaw A T.Thermal Analysis-review and prospect[J].Thermochim Acta,2000,355:35- 42.
[7]Peter D.Drug carries in medical and biology[J].Mol Pharmaceutics,2004,1(6):395-398.
[8]Hiroaki Ohno,Mitsuaki Okumura.Samarium(Ⅱ)-promoted radical spirocyclization onto an aromatic ring[J].Org Chem,2003,68(20):7 722-7 732.
[9]Chen Feixiong,Zhou Cairong,Li Guopeng.Study on thermal decomposition and the non-isothermal decomposition kinetics of glyphosate[J].Journal of Thermal Analysis and Calorimetry,2012,109:1 457-1 462.
[10]Wang Shaoxu,Zhao Zhe,Tan Zhicheng,et al.Thermal stability and kinetics of thermal decomposition for protionamid[J].Acta Physico-Chimica Sinica,2007,23(9):1459.
[11]Nopsiri Chaiyo,Rangson Muanghlua,Surasak Niemcharoen,et al.Non-isothermal kinetics of the thermal decomposition of sodium oxalate Na2C2O4[J].J Therm Anal Calorim,2012,107:1 023-1 029.
[12]刘文峰,林木良.热重法在药品稳定性及预测存放期上的应用[J].广东化工,2004(1):6-8.

Memo

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Last Update: 2013-09-30